ArticleEuropean radiology2017
Non-specific benign pathological results on transthoracic core-needle biopsy: how to differentiate false-negatives?
Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- 2020 Clinical Practice Guideline for Percutaneous Transthoracic Needle Biopsy of Pulmonary Lesions: A Consensus Statement and Recommendations of the Korean Society of Thoracic Radiology.Korean journal of radiology · 2021Guideline
- Non-diagnostic Results of Percutaneous Transthoracic Needle Biopsy: A Meta-analysis.Scientific reports · 2019Pooled it
- CT-based interpretable delta-radiomics model for risk stratification of pulmonary ground-glass nodules: a multicentre study.Insights into imaging · 2026Article
- Clinical and Research Implications of Nonspecific Necrosis on Peripheral Pulmonary Lesion Biopsies.Chest · 2026Article
- Diagnostic accuracy of percutaneous transthoracic needle biopsy among peripheral pulmonary lesions: a multicenter observational study.Annals of medicine and surgery (2012) · 2024Article
- Non-malignant pathological results from CT-guided biopsy for pulmonary nodules: a predictive model for identifying false-negative results.Journal of cardiothoracic surgery · 2024Article
- Contrast-enhanced Imaging in Peripheral Pulmonary Lesions: The Role in US-guided Biopsies.Radiology. Cardiothoracic imaging · 2024Article
- Assessment of Advanced Diagnostic Bronchoscopy Outcomes for Peripheral Lung Lesions: A Delphi Consensus Definition of Diagnostic Yield and Recommendations for Patient-centered Study Designs. An Official American Thoracic Society/American College of Chest Physicians Research Statement.American journal of respiratory and critical care medicine · 2024Article
- Machine-Learning-Based Classification Model to Address Diagnostic Challenges in Transbronchial Lung Biopsy.Cancers · 2024Article
- Subsolid pulmonary nodules: why not "watch and wait"?Annals of translational medicine · 2024Article
- Predictive Factors of Nonmalignant Pathological Diagnosis and Final Diagnosis of Ultrasound-Guided Cutting Biopsy for Peripheral Pulmonary Diseases.Canadian respiratory journal · 2023Article
- Diagnostic accuracy and safety of CT-guided percutaneous lung biopsy with a coaxial cutting needle for the diagnosis of lung cancer in patients with UIP pattern.Scientific reports · 2022Article
- Computed tomography-guided cutting needle biopsy for lung nodules: when the biopsy-based benign results are real benign.World journal of surgical oncology · 2022Article
- Computed tomography-guided core needle biopsy for sub-centimeter pulmonary nodules.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2022Article
- CT-Guided Transthoracic Biopsy of Pulmonary Lesions: Diagnostic versus Nondiagnostic Results.Diagnostics (Basel, Switzerland) · 2022Article
- Review
- Accuracy and complications of percutaneous transthoracic needle lung biopsy for the diagnosis of malignancy in patients with idiopathic pulmonary fibrosis.European radiology · 2021Article
- Preoperative computed tomography-guided coil localization of sub-centimeter lung nodules.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2021Article
- Utility of liquid-based cytology on residual needle rinses collected from core needle biopsy for lung nodule diagnosis.Cancer medicine · 2021Article
- Computed tomography-guided lung biopsy: a randomized controlled trial of low-dose versus standard-dose protocol.European radiology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine the negative predictive value (NPV) of non-specific benign results from cone-beam CT (CBCT)-guided transthoracic core-needle biopsy (TTNB) and identify predicting factors for false-negative for malignancies.
methodsFrom January 2009-December 2011, 1,108 consecutive patients with 1,116 lung lesions underwent CBCT-guided TTNB using an 18-gauge coaxial cutting needle. Among them, 226 patients with 226 TTNBs, initially diagnosed as non-specific benign, were included in this study. The medical charts, radiological or pathological follow-ups were reviewed to classify false-negative and true-negative results and to identify which variables were associated with false-negatives.
resultsOf 226 lesions, 24 (10.6%) were finally confirmed as malignancies and 202 (89.4%) as benign, of which the NPV was 89.4% (202/226). Multivariate analysis revealed that part-solid nodule (PSN) (odds ratio (OR), 3.95; P = 0.022), a biopsy result of 'granulomatous inflammation' (OR, 0.04; P = 0.022), and exact location of needle tip within targets (OR, 0.37; P = 0.045) were significantly associated with false-negatives among initial non-specific benign biopsy results.
conclusionThe NPV of the non-specific benign biopsy was 89.4%. PSN was a significant positive indicator, but a biopsy result of 'granulomatous inflammation' and exact location of needle tip within targets were significant negative indicators for false-negatives. KEY POINTS: • The negative predictive value of the non-specific benign biopsy was 89.4%. • A part-solid nodule is a significant predictor for false-negative biopsy (OR = 3.95). • Pathological diagnosis of granulomatous inflammation is a robust indicator for 'true-negatives'. • Identifying needle tip within target lesions is a significant predictor for 'true-negatives'.
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