ArticleNeurology2017
Left frontal cortex connectivity underlies cognitive reserve in prodromal Alzheimer disease.
Article in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 1 of them a synthesis that pooled it.
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Who cites it
84 citing papers in PubMed, 1 synthesis or guideline pooled it, 149 citations in OpenAlex.
- Multifactorial approaches to study bilingualism in the aging population: Past, present, future.Frontiers in psychology · 2022Pooled it
- Clinical and radiomic features for predicting the treatment response of repetitive transcranial magnetic stimulation in major neurocognitive disorder: Results from a randomized controlled trial.Human brain mapping · 2022Trial
- Machine learning assessment of cognitive reserve using functional near-infrared spectroscopy in older adults with cognitive frailty.GeroScience · 2026Article
- Modular brain networks shape amyloid-driven tau spread and cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Education, Cognitive Reserve, and Brain Pathology in Aging and Alzheimer's Disease: Evidence from Preclinical and Symptomatic Cohorts.medRxiv : the preprint server for health sciences · 2026Article
- Pathways to resilience: relationships between cognitive reserve, psychological debt, and Alzheimer's disease biomarkers.Alzheimer's research & therapy · 2026Article
- Subregional Functional Connectivity of the Precuneus as a Preclinical Biomarker in Alzheimer's Disease.Neurology research international · 2026Article
- Mechanisms and Impact of Cognitive Reserve in Normal Aging and Alzheimer's Disease.Diagnostics (Basel, Switzerland) · 2025Review
- Functional redundancy of the posterior hippocampi is selectively disrupted in non-demented older adults withNeuroimage. Reports · 2025Article
- Multimodal spatial gradients to explain regional susceptibility to fibrillar tau in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Article
- Cognitive reserve is associated with education, social determinants, and cognitive outcomes among older American Indians in the Strong Heart Study.Communications psychology · 2025Article
- Cognitive and physical activities are associated with cognitive resilience in a memory clinic cohort.Brain communications · 2025Article
- The interaction between resilience framework and neuron-astrocyte-synapse dynamics in AD.Frontiers in aging neuroscience · 2025Review
- Cognitive reserve against Alzheimer's pathology is linked to brain activity during memory formation.Nature communications · 2024Observational
- Educational disparities in brain health and dementia across Latin America and the United States.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Brain health in diverse settings: How age, demographics and cognition shape brain function.NeuroImage · 2024Article
- The characteristic pattern of functional connectivity density influenced by postmenopausal females in the preclinical stage of dementia.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The concept of resilience to Alzheimer's Disease: current definitions and cellular and molecular mechanisms.Molecular neurodegeneration · 2024Review
- Cognitive reserve predicts episodic memory enhancement induced by transcranial direct current stimulation in healthy older adults.Scientific reports · 2024Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo test whether higher global functional connectivity of the left frontal cortex (LFC) in Alzheimer disease (AD) is associated with more years of education (a proxy of cognitive reserve [CR]) and mitigates the association between AD-related fluorodeoxyglucose (FDG)-PET hypometabolism and episodic memory.
methodsForty-four amyloid-PET-positive patients with amnestic mild cognitive impairment (MCI-Aβ+) and 24 amyloid-PET-negative healthy controls (HC) were included. Voxel-based linear regression analyses were used to test the association between years of education and FDG-PET in MCI-Aβ+, controlled for episodic memory performance. Global LFC (gLFC) connectivity was computed through seed-based resting-state fMRI correlations between the LFC (seed) and each voxel in the gray matter. In linear regression analyses, education as a predictor of gLFC connectivity and the interaction of gLFC connectivity × FDG-PET hypometabolism on episodic memory were tested.
resultsFDG-PET metabolism in the precuneus was reduced in MCI-Aβ+ compared to HC (
conclusionsHigher gLFC connectivity is a functional substrate of CR that helps to maintain episodic memory relatively well in the face of emerging FDG-PET hypometabolism in early-stage AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.