Evidence map›Paper›PMID 28188253›Full record

ArticleJournal of the American Heart Association2017

Frailty, Physical Activity, and Mobility in Patients With Cardiac Implantable Electrical Devices.

Daniel B Kramer, Timothy Tsai, Poorna Natarajan, Elise Tewksbury, Susan L Mitchell, Thomas G Travison

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Toward security-aware portable sequencing.Nature communications · 2025
    Article
  5. 'Can do' versus 'Do do' in nursing home residents: identification of contextual factors discriminating groups with aligned or misaligned physical activity and physical capacity.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2024
    Article
  6. Observational
  7. Article
  8. Article
  9. A Proposed Method of Converting Gait Speed and TUG Test in Older Subjects.International journal of environmental research and public health · 2022
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. The Relationship between Frailty Syndrome and Concerns about an Implantable Cardioverter Defibrillator.International journal of environmental research and public health · 2020
    Article
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Daniel B KramerHebrew SeniorLife Institute for Aging Research, Boston, MA dkramer@bidmc.harvard.edu.
Timothy TsaiHebrew SeniorLife Institute for Aging Research, Boston, MA.
Poorna NatarajanHarvard Medical School, Boston, MA.
Elise TewksburyHarvard Medical School, Boston, MA.
Susan L MitchellHebrew SeniorLife Institute for Aging Research, Boston, MA.
Thomas G TravisonHebrew SeniorLife Institute for Aging Research, Boston, MA.
Harvard University · USHebrew SeniorLife · US

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
Midcareer Mentoring Award for Patient-Oriented Research in AgingK24AG033640 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI MITCHELL, SUSAN L · 2009 to 2018
$1.8M
Patient-Centered Outcomes of Implantable Defibrillator Therapy in Older PatientsK23AG045963 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI KRAMER, DANIEL BRUCE · 2013 to 2016
$714k
NCATS NIH HHS UL1 TR001102NIA NIH HHS K23 AG045963NIA NIH HHS K24 AG033640
6 · The paper itself

Abstract

backgroundThis study aimed to demonstrate the feasibility of measuring frailty in patients with cardiac implantable electrical devices while validating the physiologic significance of device-detected physical activity by evaluating its association with frailty and mobility. METHODS AND

resultsOutpatients with cardiac implantable electrical devices compatible with physical activity analysis with at least 7 days of data were eligible. Office testing included frailty status (Study of Osteoporotic Fractures instrument), gait speed (m/s), mobility according to the Timed Up and Go (TUG) test (seconds), and daily physical activity (h/d) as measured by cardiac implantable electrical device. Among 219 patients, Study of Osteoporotic Fractures testing found 39.7% to be robust, 47.5% prefrail, and 12.8% frail. The mean gait speed for the cohort was 0.8±0.3 m/s, mean TUG time was 10.9±4.4 seconds, and mean activity was 2.8±1.9 h/d. Frail patients were markedly more likely to have gait speeds <0.8 m/s (OR 6.25, 95% CI 1.79-33.3). In unadjusted analyses each 1-hour increase in mean daily activity was associated with a 46% reduction of frail phenotype (OR 0.54, 95% CI 0.40-0.74) versus robust and with a 27% reduction in the odds of having the prefrail phenotype (OR 0.73, 95% CI 0.62-0.86). After adjustment this association per hour of activity persisted, with an adjusted OR for frailty of 0.71 (95% CI 0.51-0.99) and adjusted OR for prefrailty of 0.81 (95% CI 0.67-0.99).

conclusionsFrailty and mobility limitation are common among cardiac implantable electrical device patients and are correlated to device-detected physical activity.

Indexed as

Defibrillators, ImplantablePacemaker, ArtificialAgedArrhythmias, CardiacCross-Sectional StudiesExerciseFemaleFollow-Up StudiesFrail ElderlyFrailtyGeriatric AssessmentHumansIncidenceMaleMassachusettsMobility Limitationagingdefibrillationpacemakerphysical exercise

Identifiers

PMID28188253
PMCPMC5523763
OpenAlexW2586063052

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.