ArticleClinical chemistry2017
Diurnal and Long-term Variation in Plasma Concentrations and Renal Clearances of Circulating Markers of Kidney Proximal Tubular Secretion.
Article in Clinical chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Tubular secretion in chronic kidney disease: from established physiology to clinical utility.Frontiers in cell and developmental biology · 2026Review
- How kidney clock works: circadian pattern of eGFR based on a population data group.Journal of physiology and biochemistry · 2023Article
- Precision Medicine in Diabetic Kidney Disease: A Narrative Review Framed by Lived Experience.Canadian journal of kidney health and disease · 2023Review
- Estimated Kidney Tubular Secretion and Kidney, Cardiovascular, and Mortality Outcomes in CKD: The Systolic Blood Pressure Intervention Trial.Kidney medicine · 2022Article
- Markers of Kidney Tubular Secretion and Risk of Adverse Events in SPRINT Participants with CKD.Journal of the American Society of Nephrology : JASN · 2022Article
- Biological variation of major gut-derived uremic toxins in the serum of healthy adult cats.Journal of veterinary internal medicine · 2021Article
- Kidney Clearance of Secretory Solutes Is Associated with Progression of CKD: The CRIC Study.Journal of the American Society of Nephrology : JASN · 2020Article
- Tubular secretion of creatinine and kidney function: an observational study.BMC nephrology · 2020Observational
- Associations between adipose tissue volume and small molecules in plasma and urine among asymptomatic subjects from the general population.Scientific reports · 2020Article
- Indoxyl Sulphate is Associated with Atrial Fibrillation Recurrence after Catheter Ablation.Scientific reports · 2018Observational
- Residual Function Effectively Controls Plasma Concentrations of Secreted Solutes in Patients on Twice Weekly Hemodialysis.Journal of the American Society of Nephrology : JASN · 2018Article
- Untargeted mass spectrometry discloses plasma solute levels poorly controlled by hemodialysis.PloS one · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe renal proximal tubule is essential for removing organic solutes and exogenous medications from the circulation. We evaluated diurnal, prandial, and long-term biological variation of 4 candidate endogenous markers of proximal tubular secretion.
methodsWe used LC-MS to measure plasma and urine concentrations of hippurate (HA), cinnamoylglycine (CMG), indoxyl sulfate (IS), and
resultsPlasma concentrations of secreted solutes varied over the 24-h baseline period. Diurnal variation was greatest for HA, followed by CMG, IS, and PCS. Plasma concentrations of HA (
conclusionsPlasma concentrations of HA, CMG, IS, and PCS fluctuate within individuals throughout the day and over weeks. Renal clearances of these secreted solutes, which serve as estimates of renal proximal tubule secretion, are also subject to intraindividual biological variation that can be improved by additional plasma measurements.
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Registered trials
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