Evidence map›Paper›PMID 28188225›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2017

Inflammation-induced caveolin-1 and BMPRII depletion promotes endothelial dysfunction and TGF-β-driven pulmonary vascular remodeling.

Suellen D S Oliveira, Maricela Castellon, Jiwang Chen, Marcelo G Bonini, Xiaowu Gu, Michael H Elliott, Roberto F Machado, Richard D Minshall

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 57 citations in OpenAlex.

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  13. Physiological functions of caveolae in endothelium.Current opinion in physiology · 2023
    Article
  14. The vascular perspective on acute and chronic lung disease.The Journal of clinical investigation · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Suellen D S OliveiraDepartment of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois.ORCID 0000-0002-7654-1909
Maricela CastellonDepartment of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois.
Jiwang ChenDepartment of Medicine, University of Illinois at Chicago, Chicago, Illinois; and.
Marcelo G BoniniDepartment of Medicine, University of Illinois at Chicago, Chicago, Illinois; and.
Xiaowu GuDepartment of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Michael H ElliottDepartment of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.
Roberto F MachadoDepartment of Medicine, University of Illinois at Chicago, Chicago, Illinois; and.
Richard D MinshallDepartment of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois; rminsh@uic.edu.
University of Illinois Chicago · USUniversity of Oklahoma Health Sciences Center · US

Funding

TRPC6 Regulation of Lung Endothelial Barrier FunctionP01HL060678 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MALIK, ASRAR B. · 2000 to 2020
$40.1M
P30-CENTER CORE GRANT FOR VISION RESEARCHP30EY021725 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Michelle C Callegan · 2011 to 2026
$10.5M
Vascular Targeting Genomic & Genetic Strategies for Acute Chest SyndromeR01HL111656 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Roberto F. Machado · 2013 to 2026
$7.9M
Role of Caveolin-1 in the Maintenance of Blood-retinal Barrier IntegrityR01EY019494 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ELLIOTT, MICHAEL H · 2010 to 2025
$4.9M
Role of Sphingolipid Pathways in the Pathobiology of PAHR01HL127342 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MACHADO, ROBERTO F., NATARAJAN, VISWANATHAN · 2016 to 2023
$4.5M
New Strategies for Treating Septic Vasculopathy Inflammation and ThrombosisR01HL125356 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BONINI, MARCELO G., DU, XIAOPING · 2014 to 2018
$3.4M
Src Regulation of Lung Endothelial Barrier FunctionR01HL071626 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MINSHALL, RICHARD D · 2003 to 2011
$2.4M
NEI NIH HHS P30 EY021725NEI NIH HHS R01 EY019494NHLBI NIH HHS P01 HL060678NHLBI NIH HHS R01 HL071626NHLBI NIH HHS R01 HL111656NHLBI NIH HHS R01 HL125356NHLBI NIH HHS R01 HL127342
6 · The paper itself

Abstract

Endothelial cell (EC) activation and vascular injury are hallmark features of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Caveolin-1 (Cav-1) is highly expressed in pulmonary microvascular ECs and plays a key role in maintaining vascular homeostasis. The aim of this study was to determine if the lung inflammatory response to

Indexed as

Vascular RemodelingActinsAcute Lung InjuryAdultAgedAnimalsBone Morphogenetic Protein Receptors, Type IIBronchoalveolar Lavage FluidCaveolin 1Cell ShapeCytokinesEndothelial CellsFemaleHumansInflammationInflammation MediatorsACTA2 protein, humanActinsBone Morphogenetic Protein Receptors, Type IICaveolin 1CytokinesInflammation MediatorsInterleukin-6LipopolysaccharidesNitric Oxide Synthase Type IIIReceptors, Transforming Growth Factor betaTransforming Growth Factor betaARDScaveolin-1endothelial dysfunctionTGF-β signalingvascular inflammationvascular remodeling

Identifiers

PMID28188225
PMCPMC5451590
OpenAlexW2587529914

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.