Evidence map›Paper›PMID 28188174›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2017

Brain atrophy in picornavirus-infected FVB mice is dependent on the H-2D

April M Huseby Kelcher, Pascal A Atanga, Jeffrey D Gamez, Luz M Cumba Garcia, Stephanie J Teclaw, Kevin D Pavelko, Slobodan I Macura, Aaron J Johnson

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Getting on your last nerve: IFNs and resistance to infection.Journal of immunology (Baltimore, Md. : 1950) · 2026
    Review
  2. Article
  3. Article
  4. Dissection of Neurotropic Theiler's Murine Encephalomyelitis Virus Induced Brain Atrophy in Single MHC Class I Mice of C57BL/6 Background.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  5. Article
  6. Myeloid cell MHC I expression drives CD8Frontiers in immunology · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

April M Huseby KelcherMayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Pascal A AtangaDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Jeffrey D GamezDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Luz M Cumba GarciaMayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, Minnesota, USA.
Stephanie J TeclawDepartment of Immunology, Mayo Clinic, Rochester, Minnesota, USA.
Kevin D PavelkoDepartment of Immunology, Mayo Clinic, Rochester, Minnesota, USA.
Slobodan I MacuraNuclear Magnetic Resonance Core Facility, Mayo Clinic, Rochester, Minnesota, USA.
Aaron J JohnsonDepartment of Immunology, Mayo Clinic, Rochester, Minnesota, USA; johnson.aaron2@mayo.edu.
University of Minnesota Rochester · USMayo Clinic · US

Funding

PHD TRAINING PROGRAM IN BASIC IMMUNOLOGYT32AI007425 · NIAID · MAYO CLINIC ROCHESTER · PI SHAPIRO, VIRGINIA SMITH · 1995 to 2020
$3.6M
Immune Contribution to Brain AtrophyR21NS094765 · NINDS · MAYO CLINIC ROCHESTER · PI JOHNSON, AARON J · 2016 to 2017
$498k
NIAID NIH HHS T32 AI007425NINDS NIH HHS R21 NS094765
6 · The paper itself

Abstract

Brain atrophy is a common feature of numerous neurologic diseases in which the role of neuroinflammation remains ill-defined. In this study, we evaluated the contribution of major histocompatibility complex class I molecules to brain atrophy in Theiler's murine encephalomyelitis virus (TMEV)-infected transgenic FVB mice that express the D

Indexed as

TheilovirusAnimalsAtrophyBrainBrain DiseasesCD8-Positive T-LymphocytesDisease Models, AnimalGene Expression RegulationGenes, MHC Class IMiceMice, Inbred StrainsMice, TransgenicNeuronsPicornaviridae InfectionsViral LoadCD8 T cellsMHC class IneurodegenerationTMEVviral clearance

Identifiers

PMID28188174
PMCPMC5434653
OpenAlexW2588209289

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.