ArticleInfectious diseases of poverty2017
Levels of insecticide resistance to deltamethrin, malathion, and temephos, and associated mechanisms in Aedes aegypti mosquitoes from the Guadeloupe and Saint Martin islands (French West Indies).
Article in Infectious diseases of poverty, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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55 citing papers in PubMed, 1 synthesis or guideline pooled it, 138 citations in OpenAlex.
- Insecticide resistance and the role of target-site insensitivity mutations among malaria vectors in China: A systematic review and meta-analysis.Parasites & vectors · 2025Pooled it
- Integrated transcriptomic and variant analysis reveals molecular mechanisms of pyrethroid resistance in a genetically homogenized Cas9 strain of Aedes aegypti.Archives of toxicology · 2026Article
- Evidence of insecticide resistance in Aedes aegypti populations of Suriname: first report of malathion resistance and presence of the kdr mutations V410L, V1016I and F1534C.Memorias do Instituto Oswaldo Cruz · 2026Article
- Multi-omics insights into mosquito insecticide resistance for integrated vector management.PeerJ · 2026Review
- Transcriptome and Functional Analyses Revealed the Carboxylesterase Genes Involved in Pyrethroid Resistance inInsects · 2025Article
- Insecticide Resistance Status ofInsects · 2025Article
- A systematic review of insecticide resistance inVeterinary world · 2025Review
- Multiplexed amplicon sequencing reveals the heterogeneous spatial distribution of pyrethroid resistance mutations in Aedes albopictus mosquito populations in southern France.Parasites & vectors · 2024Article
- Study on the cross-resistance of Aedes albopictus (Skuse) (Diptera: Culicidae) to deltamethrin and pyriproxyfen.Parasites & vectors · 2024Article
- Invasive brown algae (Sargassum spp.) as a potential source of biocontrol against Aedes aegypti.Scientific reports · 2024Article
- First detection of V410L kdr mutation in Aedes aegypti populations of Argentina supported by toxicological evidence.Parasites & vectors · 2024Article
- Uncovering the genetic diversity in Aedes aegypti insecticide resistance genes through global comparative genomics.Scientific reports · 2024Article
- Aedes aegypti CCEae3A carboxylase expression confers carbamate, organophosphate and limited pyrethroid resistance in a model transgenic mosquito.PLoS neglected tropical diseases · 2024Article
- Worldwide Status of Insecticide Resistance ofJournal of arthropod-borne diseases · 2023Review
- Knockdown of the Sodium/Potassium ATPase Subunit Beta 2 Reduces Egg Production in the Dengue Vector,Insects · 2023Article
- A zone-of-inhibition assay to screen for humoral antimicrobial activity in mosquito hemolymph.Frontiers in cellular and infection microbiology · 2023Article
- Relationship between temperature and Anopheles gambiae sensu lato mosquitoes' susceptibility to pyrethroids and expression of metabolic enzymes.Parasites & vectors · 2022Article
- Temporal Evaluation of Insecticide Resistance in Populations of the Major Arboviral VectorInsects · 2022Article
- Expansive and Diverse Phenotypic Landscape of Field Aedes aegypti (Diptera: Culicidae) Larvae with Differential Susceptibility to Temephos: Beyond Metabolic Detoxification.Journal of medical entomology · 2022Article
- A New Method to Address the Importance of Detoxified Enzyme in Insecticide Resistance - Meta-Analysis.Frontiers in physiology · 2022Article
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundIn the Guadeloupe and Saint Martin islands, Aedes aegypti mosquitoes are the only recognized vectors of dengue, chikungunya, and Zika viruses. For around 40 years, malathion was used as a mosquito adulticide and temephos as a larvicide. Since the European Union banned the use of these two insecticide molecules in the first decade of the 21st century, deltamethrin and Bacillus thuringiensis var. israelensis are the remaining adulticide and larvicide, respectively, used in Guadeloupe. In order to improve the management of vector control activities in Guadeloupe and Saint Martin, we investigated Ae. aegypti resistance to and mechanisms associated with deltamethrin, malathion, and temephos.
methodsAe. aegypti mosquitoes were collected from six different localities of Guadeloupe and Saint Martin. Larvae were used for malathion and temephos bioassays, and adult mosquitoes for deltamethrin bioassays, following World Health Organization recommendations. Knockdown resistance (Kdr) genotyping for V1016I and F1534C mutations, and expression levels of eight enzymes involved in detoxification mechanisms were examined in comparison with the susceptible reference Bora Bora strain.
resultsResistance ratios (RR
conclusionsAe. aegypti populations from Guadeloupe and Saint Martin exhibit multiple resistance to organophosphates (temephos and malathion), and pyrethroids (deltamethrin). The mechanisms associated with these resistance patterns show strong frequencies of F1534C and V1016I Kdr mutations, and an over-expression of CCEae3a, GSTe2, and four cytochrome P450 genes (014614, CYP9J23, CYP6M11, CYP6BB2). These results will form the baseline for a deeper understanding of the insecticide resistance levels and associated mechanisms of Ae. aegypti populations and will be used to improve vector control strategies in Guadeloupe and Saint Martin.
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