Evidence map›Paper›PMID 28187777›Full record

ArticleStem cell research & therapy2017

GMP-conformant on-site manufacturing of a CD133

Anna Skorska, Paula Müller, Ralf Gaebel, Jana Große, Heiko Lemcke, Cornelia A Lux, Manuela Bastian, Frauke Hausburg, Nicole Zarniko, Sandra Bubritzki and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Cell Therapy in the Treatment of Coronary Heart Disease.International journal of molecular sciences · 2023
    Review
  4. Review
  5. Article
  6. CD271Cells · 2019
    Article
  7. Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Anna SkorskaReference and Translation Center for Cardiac Stem Cell Therapy (RTC), Department of Cardiac Surgery, Rostock University Medical Center, Schillingallee 68, Rostock, 18057, Germany.
Paula MüllerReference and Translation Center for Cardiac Stem Cell Therapy (RTC), Department of Cardiac Surgery, Rostock University Medical Center, Schillingallee 68, Rostock, 18057, Germany.
Ralf GaebelReference and Translation Center for Cardiac Stem Cell Therapy (RTC), Department of Cardiac Surgery, Rostock University Medical Center, Schillingallee 68, Rostock, 18057, Germany.
Jana GroßeReference and Translation Center for Cardiac Stem Cell Therapy (RTC), Department of Cardiac Surgery, Rostock University Medical Center, Schillingallee 68, Rostock, 18057, Germany.
Heiko LemckeReference and Translation Center for Cardiac Stem Cell Therapy (RTC), Department of Cardiac Surgery, Rostock University Medical Center, Schillingallee 68, Rostock, 18057, Germany.
Cornelia A LuxReference and Translation Center for Cardiac Stem Cell Therapy (RTC), Department of Cardiac Surgery, Rostock University Medical Center, Schillingallee 68, Rostock, 18057, Germany.
Manuela BastianInstitute for Clinical Chemistry and Laboratory Medicine (ILAB), Rostock University Medical Center, Ernst-Heydemann-Straße 6, Rostock, 18057, Germany.
Frauke HausburgReference and Translation Center for Cardiac Stem Cell Therapy (RTC), Department of Cardiac Surgery, Rostock University Medical Center, Schillingallee 68, Rostock, 18057, Germany.
Nicole ZarnikoReference and Translation Center for Cardiac Stem Cell Therapy (RTC), Department of Cardiac Surgery, Rostock University Medical Center, Schillingallee 68, Rostock, 18057, Germany.
Sandra BubritzkiDepartment of Cardiac Surgery, Rostock University Medical Center, Schillingallee 35, Rostock, 18057, Germany.
Ulrike RuchReference and Translation Center for Cardiac Stem Cell Therapy (RTC), Department of Cardiac Surgery, Rostock University Medical Center, Schillingallee 68, Rostock, 18057, Germany.
Gudrun TiedemannReference and Translation Center for Cardiac Stem Cell Therapy (RTC), Department of Cardiac Surgery, Rostock University Medical Center, Schillingallee 68, Rostock, 18057, Germany.
Robert DavidReference and Translation Center for Cardiac Stem Cell Therapy (RTC), Department of Cardiac Surgery, Rostock University Medical Center, Schillingallee 68, Rostock, 18057, Germany.
Gustav SteinhoffDepartment Life, Light and Matter of the Interdisciplinary Faculty at Rostock University, Albert-Einstein Straße 25, Rostock, 18059, Germany. gustav.steinhoff@med.uni-rostock.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCD133

methodsCD133

resultsWe established for the first time an on-site manufacturing procedure for stem CPs intended for the treatment of ischemic heart diseases using an automatized system. On average, 0.88 × 10

conclusionsOur results indicate that the Prodigy is a powerful system for automatic manufacturing of a CD133

Indexed as

Hematopoietic Stem Cell TransplantationAC133 AntigenAgedAnimalsAutomation, LaboratoryBiomarkersBone Marrow CellsCell DifferentiationCell ProliferationCell SeparationDisease Models, AnimalFemaleGene ExpressionHematopoietic Stem CellsHumansMaleAC133 AntigenBiomarkersProm1 protein, mouseAdult hematopoietic stem cellsAdvanced therapy medicinal product (ATMP)Cardiovascular regenerationCD133+ cellsClinical translationGood Manufacturing Practice (GMP)ProdigyStem cell transplantation

Identifiers

PMID28187777
PMCPMC5303262

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.