ArticleBMC pediatrics2017
The association between vancomycin trough concentrations and acute kidney injury in the neonatal intensive care unit.
Article in BMC pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Vancomycin in neonatal patients: systematic review and call for standardized dosing and monitoring practices.European journal of clinical pharmacology · 2025Pooled it
- Risk Factors for Nephrotoxicity Among Neonates Receiving Vancomycin: A Systematic Review and Meta-analysis.Paediatric drugs · 2025Pooled it
- Incidence and risk factors of drug-induced kidney injury in children: a systematic review and meta-analysis.European journal of clinical pharmacology · 2023Pooled it
- Relationship between Vancomycin Trough Serum Concentrations and Clinical Outcomes in Children: a Systematic Review and Meta-Analysis.Antimicrobial agents and chemotherapy · 2022Pooled it
- Closed multilumen infusion system reduces CLABSI and antibiotic exposure in very preterm neonates.BMJ paediatrics open · 2026Article
- Incidence and risk factors of vancomycin-associated nephrotoxicity among neonates in the intensive care unit: a retrospective cohort study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Incidence of Antimicrobial-Associated Acute Kidney Injury in Children: A Structured Review.Paediatric drugs · 2024Review
- Evaluation of an Empiric Vancomycin Dosing Protocol on Goal Troughs and Acute Kidney Injury in a Neonatal Intensive Care Unit.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2023Article
- Population pharmacokinetics of vancomycin in very low birth weight neonates.Frontiers in pediatrics · 2023Article
- Sorting Out the Risks and Benefits of the #797 Recommended Intrapartum Vancomycin Dosing Approach.Antibiotics (Basel, Switzerland) · 2022Article
- Assessment of initial vancomycin trough levels and risk factors of vancomycin-induced nephrotoxicity in neonates.European journal of hospital pharmacy : science and practice · 2022Article
- Clinical Application Value of Pharmacokinetic Parameters of Vancomycin in Children Treated in the Pediatric Intensive Care Unit.Frontiers in pediatrics · 2022Article
- Amikacin or Vancomycin Exposure Alters the Postnatal Serum Creatinine Dynamics in Extreme Low Birth Weight Neonates.International journal of environmental research and public health · 2021Article
- Achieving Vancomycin Troughs Within Goal Range in Low Birth Weight Neonates.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2021Article
- AUC- vs. Trough-Guided Monitoring of Vancomycin in Infants.Indian journal of pediatrics · 2020Article
- Vancomycin-associated acute kidney injury in Hong Kong in 2012-2016.BMC nephrology · 2020Article
- Challenges of Vancomycin Dosing and Therapeutic Monitoring in Neonates.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2020Review
- Continuous Infusion Vancomycin in Pediatric Patients: A Critical Review of the Evidence.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2020Review
- Evaluating the Relationship between Vancomycin Trough Concentration and 24-Hour Area under the Concentration-Time Curve in Neonates.Antimicrobial agents and chemotherapy · 2018Article
- A population pharmacokinetic model for individualised dosage regimens of vancomycin in Chinese neonates and young infants.Oncotarget · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVancomycin has recently gained popularity as an empiric therapy for late onset sepsis in the NICU. Changes in resistance patterns in common organisms has resulted in targeting higher trough concentrations of vancomycin. Consequently, an increase in vancomycin associated nephrotoxicity has been speculated. The objective of this study is to compare the incidence of acute kidney injury (AKI) in neonates with serum vancomycin trough concentrations less than 10 mg/L, 10-15 mg/L, or greater than 15 mg/L.
methodsA retrospective chart review of patients in the neonatal intensive care unit (NICU) was conducted to determine the incidence of AKI in neonates receiving vancomycin.
resultsThe overall incidence of AKI was 2.7%. Comparison of the incidence of AKI in the three groups using Mantel-Haenszel Chi-Square test showed a statistically significant association between increasing vancomycin trough concentration and incidence of AKI.
conclusionThere is a low incidence of AKI in neonates receiving vancomycin. However, there is a positive correlation between increasing vancomycin trough concentrations and an increasing serum creatinine.
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Registered trials
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