Evidence map›Paper›PMID 28187742›Full record

ArticleJournal of neuroinflammation2017

Regulatory role of cytosolic phospholipase A

Yafa Fetfet Malada-Edelstein, Nurit Hadad, Rachel Levy

Open access · goldAbstract read
In one paragraph

Article in Journal of neuroinflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. cPLACytotechnology · 2025
    Article
  2. Review
  3. Article
  4. Functions and mechanisms of cytosolic phospholipase ANeural regeneration research · 2023
    Review
  5. Article
  6. Article
  7. Early upregulation of cytosolic phospholipase AJournal of neuroinflammation · 2021
    Article
  8. Review
  9. Small-molecule inhibitors as potential therapeutics and as tools to understand the role of phospholipases ABiochimica et biophysica acta. Molecular and cell biology of lipids · 2019
    Review
  10. Review
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yafa Fetfet Malada-EdelsteinInfectious Diseases Laboratory, Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105, Beer-Sheva, Israel.
Nurit HadadInfectious Diseases Laboratory, Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105, Beer-Sheva, Israel.
Rachel LevyInfectious Diseases Laboratory, Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 84105, Beer-Sheva, Israel. ral@bgu.ac.il.
Ben-Gurion University of the Negev · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aberrant expression of CD40, a co-stimulatory receptor found on the antigen-presenting cells, is involved in the pathogenesis of various degenerative diseases. Our previous study demonstrated that the reduction of cytosolic phospholipase A

methodsCultures of primary mouse microglia or BV-2 microglia cell line exposed to lipopolysaccharide (LPS) or interferon gamma (IFNγ) for different periods of time, in order to study the role of cPLA

resultsAddition of LPS or IFNγ caused a significant upregulation of cPLA

conclusionsOur results show for the first time that cPLA

Indexed as

AnimalsAnimals, NewbornCD40 AntigensCell Line, TransformedCells, CulturedDose-Response Relationship, DrugGroup IV Phospholipases A2MiceMice, Inbred C57BLMicrogliaTumor Necrosis Factor-alphaCD40 AntigensGroup IV Phospholipases A2Tumor Necrosis Factor-alphaCD40Cytosolic phospholipase A2αInterferon gammaLipopolysaccharideMicrogliaNuclear factor-κB

Identifiers

PMID28187742
PMCPMC5303221
OpenAlexW2587015744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.