ArticleOncotarget2017
Comparison of analytic performances of Cellsearch and iFISH approach in detecting circulating tumor cells.
Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical diagnostic biomarker "circulating tumor cells" in breast cancer - a meta-analysis.Frontiers in oncology · 2023Pooled it
- Adhesion strength of tumor cells predicts metastatic disease in vivo.Cell reports · 2025Article
- Circulating tumor cells are a good predictor of tumor recurrence in clinical patients with gastric cancer.Scientific reports · 2024Article
- Article
- Accurate prostate cancer detection based on enrichment and characterization of prostate cancer specific circulating tumor cells.Cancer medicine · 2023Article
- Factors influencing the diagnostic and prognostic values of circulating tumor cells in breast cancer: a meta-analysis of 8,935 patients.Frontiers in oncology · 2023Review
- Exosomal circRNAs as promising liquid biopsy biomarkers for glioma.Frontiers in immunology · 2023Review
- Accurate Screening for Early-Stage Breast Cancer by Detection and Profiling of Circulating Tumor Cells.Cancers · 2022Article
- Article
- Relationship between circulating tumor cells undergoing EMT and short-term efficacy following interventional treatment in patients with hepatocellular carcinoma.Journal of interventional medicine · 2020Article
- Molecular Profiles of Brain and Pulmonary Metastatic Disease in Cancer of Unknown Primary.The oncologist · 2020Article
- Determination of the optimal detection time of circulating tumor cells for the postoperative monitoring of colorectal cancer.Oncology letters · 2020Article
- Noninvasive circulating tumor cell and urine cellularTranslational cancer research · 2019Article
- Clinical significance of detecting circulating tumor cells in patients with esophageal squamous cell carcinoma by EpCAM‑independent enrichment and immunostaining‑fluorescence in situ hybridization.Molecular medicine reports · 2019Article
- Epithelial membrane protein 2: a novel biomarker for circulating tumor cell recovery in breast cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019Article
- Establishment and Characterization of a CTC Cell Line from Peripheral Blood of Breast Cancer Patient.Journal of Cancer · 2019Article
- Clinical significance of circulating tumor cells via combined whole exome sequencing in early stage cancer screening: A case report.Experimental and therapeutic medicine · 2018Article
- Liquid biopsy in pancreatic cancer: the beginning of a new era.Oncotarget · 2018Review
- Application of a novel liquid biopsy in patients with hepatocellular carcinoma undergoing liver transplantation.Oncology letters · 2018Article
- Characterization of circulating tumor cells in newly diagnosed breast cancer.Oncology letters · 2018Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circulating tumor cells (CTCs) have been widely used to predict the prognosis of breast cancer patients. The aim of the present study was to compare the performances of Cellsearch and immunostaining-fluorescence in situ hybridization (iFISH) in detecting CTCs in breast cancer patients. Forty-five newly diagnosed breast cancer patients and 14 healthy donors were recruited and their CTCs were detected by both Cellsearch and iFISH. Correlation between clinicopathological features and CTCs was investigated. We found that the positive rate of CTC detected by iFISH was significantly higher than by Cellsearch system (91% vs 38%). The CTC count, detected either by iFISH or Cellsearch, was not significantly associated with clinical pictures of patients with breast cancer. Therefore, we concluded that, compared to conventional Cellsearch CTC detection, in situ karyotypic identification performed by iFISH had higher detection rate. Therefore, iFISH may be more clinically useful than Cellsearch system.
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