ArticleAndrology2017
Male caffeine and alcohol intake in relation to semen parameters and in vitro fertilization outcomes among fertility patients.
Article in Andrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00011713 (Human Exposure to Bisphenol A, Phthalates and Fertility, Pregnancy Outcomes.), which is not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Human Exposure to Bisphenol A, Phthalates and Fertility, Pregnancy Outcomes.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Targeting Modifiable Risks: Molecular Mechanisms and Population Burden of Lifestyle Factors on Male Genitourinary Health.International journal of molecular sciences · 2025Pooled it
- The association between caffeine and alcohol consumption and IVF/ICSI outcomes: A systematic review and dose-response meta-analysis.Acta obstetricia et gynecologica Scandinavica · 2022Pooled it
- The influence of unhealthy lifestyle on semen quality: results from a cross-sectional study and Mendelian randomization analysis.Annals of medicine and surgery (2012) · 2026Article
- Article
- Review
- Mendelian randomization reveals the impact of diet on infertility in men and women.Frontiers in endocrinology · 2024Article
- How Food Choices Impact on Male Fertility.Current nutrition reports · 2023Review
- Association of male fatty acid intake with fecundability among couples planning pregnancy.Human reproduction (Oxford, England) · 2023Article
- The Role of Dietary Nutrients in Male Infertility: A Review.Life (Basel, Switzerland) · 2023Review
- [Impact of lifestyle and environmental factors on male reproductive health].Urologie (Heidelberg, Germany) · 2022Review
- Protein-rich food intake and risk of spontaneous abortion: a prospective cohort study.European journal of nutrition · 2022Article
- Diet and human reproductive system: Insight of omics approaches.Food science & nutrition · 2022Review
- A dietary score representing the overall relation of men's diet with semen quality in relation to outcomes of infertility treatment with assisted reproduction.F&S reports · 2021Article
- Association between intake of soft drinks and testicular function in young men.Human reproduction (Oxford, England) · 2021Article
- Do aging, drinking, and having unhealthy weight have a synergistic impact on semen quality?Journal of assisted reproduction and genetics · 2021Article
- Men's dietary patterns in relation to infertility treatment outcomes among couples undergoing in vitro fertilization.Journal of assisted reproduction and genetics · 2021Article
- Can Nutrition Help in the Treatment of Infertility?Preventive nutrition and food science · 2021Review
- Male Preconception Marijuana Use and Spontaneous Abortion: A Prospective Cohort Study.Epidemiology (Cambridge, Mass.) · 2021Article
- Impact of environmental toxin exposure on male fertility potential.Translational andrology and urology · 2020Review
- Substance Abuse and Male Hypogonadism.Journal of clinical medicine · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Much of the literature on the impact of male caffeine and alcohol intake on reproductive outcomes has utilized semen quality as a proxy for male fertility, although semen parameters have a limited predictive value for spontaneous pregnancy. The objective of this study was to investigate whether male caffeine and alcohol intakes are associated with semen parameters and assisted reproductive technology outcome. The Environment and Reproductive Health Study, an ongoing prospective cohort study, enrolls subfertile couples presenting for treatment at an academic fertility center (2007-2012). A total of 171 men with 338 semen analyses and 205 assisted reproductive technology cycles were included in this analysis. Diet was assessed using a 131-item food frequency questionnaire. Mixed models adjusting for potential confounders were used to evaluate the relationships of male caffeine and alcohol intakes with semen parameters and assisted reproductive technology outcomes. There was no association between male caffeine and alcohol intake and semen quality. Male caffeine intake was negatively related to live birth after assisted reproductive technologies (p-trend < 0.01), and male alcohol intake was positively related to live birth after assisted reproductive technologies (p-trend = 0.04). Adjusted live birth rate among couples with a male partner in the highest quartile of caffeine intake (≥272 mg/day) compared to couples with a male partner in the lowest quartile of intake (<99 mg/day) was 19% vs. 55%, respectively, p < 0.01. In terms of alcohol intake, adjusted live birth rate among couples with a male partner in the highest quartile of alcohol intake (≥22 g/day) compared to couples with a male partner in the lowest quartile of intake (<3 g/day) was 61% vs. 28%, respectively, p = 0.05. In conclusion, male pre-treatment caffeine and alcohol intakes were associated with live birth after assisted reproductive technologies, but not with semen parameters, among fertility patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.