Evidence map›Paper›PMID 28187437›Full record

ReviewOncotarget2017

Dysregulation of miRNAs in bladder cancer: altered expression with aberrant biogenesis procedure.

Fan Dong, Tianyuan Xu, Yifan Shen, Shan Zhong, Shanwen Chen, Qiang Ding, Zhoujun Shen

Open access · diamondAbstract readReview
In one paragraph

Review in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.

  1. Pooled it
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  13. MicroRNAs and target molecules in bladder cancer.Medical oncology (Northwood, London, England) · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Fan DongDepartment of Urology, Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Tianyuan XuDepartment of Urology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
Yifan ShenDepartment of Urology, Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Shan ZhongDepartment of Urology, Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Shanwen ChenDepartment of Urology, Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Qiang DingDepartment of Urology, Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Zhoujun ShenDepartment of Urology, Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, China.
Huashan Hospital · CNFudan University · CNRuijin Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aberrant expression profiles of miRNAs are widely observed in the clinical tissue specimens and urine samples as well as the blood samples of bladder cancer patients. These profiles are closely related to the pathological features of bladder cancer, such as the tumour stage/grade, metastasis, recurrence and chemo-sensitivity. MiRNA biogenesis forms the basis of miRNA expression and function, and its dysregulation has been shown to be essential for variations in miRNA expression profiles as well as tumourigenesis and cancer progression. In this review, we summarize the up-to-date and widely reported miRNAs in bladder cancer that display significantly altered expression. We then compare the miRNA expression profiles among three different sample types (tissue, urine and blood) from patients with bladder cancer. Moreover, for the first time, we outline the dysregulated miRNA biogenesis network in bladder cancer from different levels and analyse its possible relationship with aberrant miRNA expression and the pathological characteristics of the disease.

Indexed as

Gene Expression Regulation, NeoplasticAnimalsEpigenesis, GeneticGenetic VariationHumansMicroRNAsOpen Reading FramesRNA StabilityTranscription FactorsTranscription, GeneticUrinary Bladder NeoplasmsMicroRNAsTranscription Factorsbiogenesis procedurebladder cancerexpression profilemicroRNA

Identifiers

PMID28187437
PMCPMC5432357
OpenAlexW2586880266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.