Evidence map›Paper›PMID 28187340›Full record

ReviewCurrent opinion in biotechnology2017

Advances in the clinical translation of nanotechnology.

David A Scheinberg, Jan Grimm, Daniel A Heller, Evan P Stater, Michelle Bradbury, Michael R McDevitt

Abstract readReview
In one paragraph

Review in Current opinion in biotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David A ScheinbergMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: scheinbd@mskcc.org.
Jan GrimmMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Daniel A HellerMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Evan P StaterMolecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Michelle BradburyRadiology Department, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Michael R McDevittRadiology Department, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
TREATMENT OF CANCER PATIENTS WITH THYMIC FACTORSP01CA033049 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI HOUGHTON, ALAN N. · 1985 to 2009
$19.8M
Real-time Intraoperative Imaging of Cancer Biomarkers and Peripheral NervesU54CA199081 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S. · 2015 to 2019
$8.3M
RECOMBINANT ANTICD33 ANTIBODY FOR AMLR01CA055349 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SCHEINBERG, DAVID A · 1991 to 2020
$6.8M
Transient Metabolite Detection for Single-Cell Metabolomics and DiagnosticsDP2HD075698 · NICHD · SLOAN-KETTERING INST CAN RESEARCH · PI HELLER, DANIEL ALAN · 2012 to 2012
$2.7M
Renally Excreted Multimodal Core-Shell Silica Nanoparticles as Tumor-Selective RaR01CA161280 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI BRADBURY, MICHELLE S, WIESNER, ULRICH · 2012 to 2016
$2.7M
NCI NIH HHS P01 CA033049NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA055349NCI NIH HHS R01 CA161280NCI NIH HHS U54 CA199081NICHD NIH HHS DP2 HD075698
6 · The paper itself

Abstract

The use of novel materials in the nano-scale size range for applications in devices, drugs and diagnostic agents comes with a number of new opportunities, and also serious challenges to human applications. The larger size of particulate-based agents, as compared to traditional drugs, allows for the significant advantages of multivalency and multi-functionality. However, the human use of nanomaterials requires a thorough understanding of the biocompatibility of the synthetic molecules and their complex pharmacology. Possible toxicities created by the unusual properties of the nanoparticles are neither well-understood, nor predictable yet. A key to the successful use of the burgeoning field of nanomaterials as diagnostic and therapeutic agents will be to appropriately match the biophysical features of the particle to the disease system to be evaluated or treated.

Indexed as

Diagnostic ImagingGenetic TherapyHumansNanostructuresNanotechnologyNeoplasmsTranslational Research, Biomedical

Identifiers

PMID28187340
PMCPMC5544552

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.