Evidence map›Paper›PMID 28187226›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2017

Effects of Cholecalciferol vs Calcifediol on Total and Free 25-Hydroxyvitamin D and Parathyroid Hormone.

Albert Shieh, Christina Ma, Rene F Chun, Sten Witzel, Brandon Rafison, Hannah T M Contreras, Jonas Wittwer-Schegg, Leon Swinkels, Tonnie Huijs, Martin Hewison and 1 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Trial
  4. Trial
  5. Calcifediol is superior to cholecalciferol in improving vitamin D status in postmenopausal women: a randomized trial.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021
    Trial
  6. Trial
  7. Trial
  8. Trial
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Vitamin D and COVID-19-Revisited.Journal of internal medicine · 2022
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

Albert ShiehDepartment of Medicine.
Christina MaDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095.
Rene F ChunDepartment of Orthopaedic Surgery, and.
Sten WitzelDepartment of Orthopaedic Surgery, and.
Brandon RafisonDepartment of Orthopaedic Surgery, and.
Hannah T M ContrerasDepartment of Orthopaedic Surgery, and.
Jonas Wittwer-ScheggDSM Nutritional Products, 4303 Kaiseraugst, Switzerland.
Leon SwinkelsFuture Diagnostics, 6603 BN Wijchen, the Netherlands.
Tonnie HuijsFuture Diagnostics, 6603 BN Wijchen, the Netherlands.
Martin HewisonInstitute of Metabolism and Systems Research, The University of Birmingham, Birmingham B15 2TT, United Kingdom.
John S AdamsDepartment of Orthopaedic Surgery, and.
Future Diagnostics (Netherlands) · NLDSM (Switzerland) · CHUniversity of Birmingham · GBUniversity of California, Los Angeles · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Vitamin D Metabolism in LeprosyP50AR063020 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ADAMS, JOHN S · 2012 to 2016
$7.8M
DBP and the bioavailability and function of vitamin DR01AR063910 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ADAMS, JOHN S, HEWISON, MARTIN · 2013 to 2017
$1.8M
Impact of ethnicity in the gut microbiome in response to oral vitamin D replacementR21AR073018 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ADAMS, JOHN S · 2017 to 2017
$302k
NCATS NIH HHS UL1 TR000124NIAMS NIH HHS P50 AR063020NIAMS NIH HHS R01 AR063910NIAMS NIH HHS R21 AR073018
6 · The paper itself

Abstract

contextVitamin D deficiency disproportionately affects nonwhite individuals. Controversy persists over how to best restore low 25D levels, and how to best define vitamin D status [total (protein bound plus free) vs free 25D].

objectiveTo assess the effects of vitamin D3 (cholecalciferol, or D3) vs 25-hydroxyvitamin D3 (calcifediol, or 25D3) on total and free 25D in a multiethnic cohort of adults, and whether change in parathyroid hormone (PTH) is more strongly associated with total vs free 25D.

designSixteen-week randomized controlled trial. Biochemistries at 0, 4, 8, and 16 weeks.

settingAcademic medical center.

participantsThirty-five adults ≥18 years of age with 25D levels <20 ng/mL.

interventionSixty micrograms (2400 IU)/d of D3 or 20 μg/d of 25D3.

main outcome measuresTotal and free 25D, and PTH.

resultsBaseline total (16.2 ± 3.7 vs 17.0 ± 2.5 ng/mL; P = 0.4) and free (4.2 ± 0.8 vs 4.7 ± 1.0 pg/mL; P = 0.2) 25D were similar between D3 and 25D3 groups, respectively; 25D3 increased total (+25.5 vs +13.8 ng/mL; P = 0.001) and free (+6.6 vs +3.5 pg/mL; P = 0.03) 25D more than D3. By 4 weeks, 87.5% of 25D3 participants had total 25D levels ≥30 ng/mL, compared with 23.1% of D3 participants (P = 0.001). Change in PTH was associated with both total (P = 0.01) and free 25D (P = 0.04).

conclusions25D3 increased total and free 25D levels more rapidly than D3, regardless of race/ethnicity. Free and total 25D were similarly associated with change in PTH.

Indexed as

AdultCalcifediolCalciumCholecalciferolFemaleHumansMaleMiddle AgedParathyroid HormoneVitamin DVitamin D DeficiencyYoung Adult25-hydroxyvitamin DCalcifediolCalciumCholecalciferolParathyroid HormoneVitamin D

Identifiers

PMID28187226
PMCPMC5460735
OpenAlexW2587831093

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.