ArticleAnnals of surgery2018
Apolipoprotein L1 and Chronic Kidney Disease Risk in Young Potential Living Kidney Donors.
Article in Annals of surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Health Disparities in Kidney Transplantation for African Americans.American journal of nephrology · 2017Pooled it
- Insights From Black Living Kidney Donors: An Interview Study on APOL1 Genetic Testing Experiences.Clinical transplantation · 2026Observational
- Development and Evaluation of a Culturally TargetedKidney medicine · 2025Article
- Strategies for choosing the best living donor: A review of the literature and a proposal of a decision-making paradigm.Pediatric transplantation · 2024Review
- Article
- APOL1 Kidney Risk Variants and Long-Term Kidney Function in Healthy Middle-Aged Black Individuals: The Atherosclerosis Risk in Communities (ARIC) Study.Kidney medicine · 2024Article
- Sociodemographic Disparities in Adults with Kidney Failure: A Meta-Analysis.Diseases (Basel, Switzerland) · 2024Review
- A Scoping Review of Kidney Transplantation in Africa: How Far have We Come?World journal of surgery · 2023Article
- Implementation of a culturally competentBMJ open · 2023Article
- Ethical Challenge of Apolipoprotein L1 Testing in Potential Kidney Donors: A Case-Based Editorial.Kidney medicine · 2023Article
- Predicting resectability of primary tumor and mesenteric lymph-node masses in patients with small-intestine neuroendocrine tumors.Updates in surgery · 2022Article
- The evolving story of apolipoprotein L1 nephropathy: the end of the beginning.Nature reviews. Nephrology · 2022Review
- Impact of education on APOL1 testing attitudes among prospective living kidney donors.Clinical transplantation · 2022Article
- Living kidney donation in a developing country.PloS one · 2022Article
- Apoprotein L1 risk variants and kidney transplantation: a protocol for systematic review and meta-analysis.The Pan African medical journal · 2022Article
- Diabetes-free survival among living kidney donors and non-donors with obesity: A longitudinal cohort study.PloS one · 2022Article
- APOL1 genotyping in kidney transplantation: to do or not to do, that is the question? (pro).Kidney international · 2021Article
- Effects of living kidney donation on arterial stiffness: a systematic review protocol.BMJ open · 2021Article
- The first increase in live kidney donation in the United States in 15 years.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020Article
- Apolipoprotein L1: role in the evaluation of kidney transplant donors.Current opinion in nephrology and hypertension · 2020Article
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveThe aim of this study was to develop a novel chronic kidney disease (CKD) risk prediction tool for young potential living kidney donors. SUMMARY OF BACKGROUND DATA: Living kidney donor selection practices have evolved from examining individual risk factors to a risk calculator incorporating multiple characteristics. Owing to limited long-term data and lack of genetic information, current risk tools lack precision among young potential living kidney donors, particularly African Americans (AAs).
methodsWe identified a cohort of young adults (18-30 years) with no absolute contraindication to kidney donation from the longitudinal cohort study Coronary Artery Risk Development in Young Adults. Risk associations for CKD (estimated glomerular filtration rate <60 mL/min/1.73 m) were identified and assigned weighted points to calculate risk scores.
resultsA total of 3438 healthy adults were identified [mean age 24.8 years; 48.3% AA; median follow-up 24.9 years (interquartile range: 24.5-25.2)]. For 18-year olds, 25-year projected CKD risk varied by ethnicity and sex even without baseline clinical and genetic abnormalities; risk was 0.30% for European American (EA) women, 0.52% for EA men, 0.52% for AA women, 0.90% for AA men. Among 18-year-old AAs with apolipoprotein L1 gene (APOL1) renal-risk variants without baseline abnormalities, 25-year risk significantly increased: 1.46% for women and 2.53% for men; among those with 2 APOL1 renal-risk variants and baseline abnormalities, 25-year risk was higher: 2.53% to 6.23% for women and 4.35% to 10.58% for men.
conclusionsYoung AAs were at highest risk for CKD, and APOL1 renal-risk variants drove some of this risk. Understanding the genetic profile of young AA potential living kidney donors in the context of baseline health characteristics may help to inform candidate selection and counseling.
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Registered trials
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