Observational studyBMJ open2016
Missed opportunities for earlier diagnosis of HIV in patients who presented with advanced HIV disease: a retrospective cohort study.
Observational study in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Health-Related Quality of Life in People with Advanced HIV Disease, from 1996 to 2021: Systematic Review and Meta-analysis.AIDS and behavior · 2024Pooled it
- Missed opportunities for HIV diagnosis in Mexico City: unveiling the sex gap.Frontiers in reproductive health · 2026Article
- Call to action: A roadmap for HIV prevention and PrEP adoption in the Gulf region.International journal of STD & AIDS · 2026Review
- Outcomes 10 Years After Implementing an Emergency Department Opt-out Bloodborne Virus Screening Program.Open forum infectious diseases · 2025Article
- Missed opportunities for early HIV diagnosis in Greece: The MORFEAS study, 2019 to 2021.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024Article
- Adherence to CDC Guidelines for mpox Evaluation: Practice Patterns Across an Academic Medical System During the 2022 Epidemic.Open forum infectious diseases · 2024Article
- Missed Opportunities for HIV Diagnosis and Their Clinical Repercussions in the Portuguese Population-A Cohort Study.Pathogens (Basel, Switzerland) · 2024Article
- High prevalence of late presentation with advanced HIV disease and its predictors among newly diagnosed patients in Kumasi, Ghana.BMC infectious diseases · 2024Article
- Analysing Early Diagnosis Strategies for HIV Infection: A Retrospective Study of Missed Diagnostic Opportunities.Healthcare (Basel, Switzerland) · 2024Article
- Article
- Two pandemics intertwined around one patient: Interstitial pneumonia as the first presentation of HIV/AIDS, be itHeliyon · 2023Article
- Advanced HIV disease and health-related suffering-exploring the unmet need of palliative care.The lancet. HIV · 2023Review
- Determinants of Direct Costs of HIV-1 Outpatient Care in Israel.International journal of environmental research and public health · 2022Article
- Delayed presentation of HIV among older individuals: a growing problem.The lancet. HIV · 2022Review
- Individualized Provider Feedback Increased HIV and HCV Screening and Identification in a New York City Emergency Department.AIDS patient care and STDs · 2022Article
- Missed opportunities for earlier diagnosis of HIV infection in people living with HIV in Thailand.PLOS global public health · 2022Article
- Article
- Epidemiology and Transmitted HIV-1 Drug Resistance among Treatment-Naïve Individuals in Israel, 2010-2018.Viruses · 2021Article
- Promoting HIV indicator condition-guided testing in hospital settings (PROTEST 2.0): study protocol for a multicentre interventional study.BMC infectious diseases · 2021Article
- Current evidence on the adoption of indicator condition guided testing for HIV in western countries: A systematic review and meta-analysis.EClinicalMedicine · 2021Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo quantify and characterise missed opportunities for earlier HIV diagnosis in patients diagnosed with advanced HIV.
designA retrospective observational cohort study.
settingA central tertiary medical centre in Israel. MEASURES: The proportion of patients with advanced HIV, the proportion of missed opportunities to diagnose them earlier, and the rate of clinical indicator diseases (CIDs) in those patients.
resultsBetween 2010 and 2015, 356 patients were diagnosed with HIV, 118 (33.4%) were diagnosed late, 57 (16%) with advanced HIV disease. Old age (OR=1.45 (95% CI 1.16 to 1.74)) and being heterosexual (OR=2.65 (95% CI 1.21 to 5.78)) were significant risk factors for being diagnosed late. All patients with advanced disease had at least one CID that did not lead to an HIV test in the 5 years prior to AIDS diagnosis. The median time between CID and AIDS diagnosis was 24 months (IQR 10-30). 60% of CIDs were missed by a general practitioner and 40% by a specialist.
conclusionsMissed opportunities to early diagnosis of HIV occur in primary and secondary care. Lack of national guidelines, lack of knowledge regarding CIDs and communication barriers with patients may contribute to a late diagnosis of HIV.
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