ArticleIEEE transactions on medical imaging2017
Multi-Modality Imaging Enables Detailed Hemodynamic Simulations in Dissecting Aneurysms in Mice.
Article in IEEE transactions on medical imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Mechanisms of aortic dissection: From pathological changes to experimental andProgress in materials science · 2025Article
- Transfer learning on physics-informed neural networks for tracking the hemodynamics in the evolving false lumen of dissected aorta.Nexus (New York, N.Y.) · 2024Article
- Central Artery Hemodynamics in Angiotensin II-Induced Hypertension and Effects of Anesthesia.Annals of biomedical engineering · 2024Article
- Method for estimating pulsatile wall shear stress from one-dimensional velocity waveforms.Physiological reports · 2023Article
- Aortic dissection detection and thrombus structure quantification using volumetric ultrasound, histology, and scanning electron microscopy.JVS-vascular science · 2023Article
- Evolving Mural Defects, Dilatation, and Biomechanical Dysfunction in Angiotensin II-Induced Thoracic Aortopathies.Arteriosclerosis, thrombosis, and vascular biology · 2022Article
- mTOR inhibition prevents angiotensin II-induced aortic rupture and pseudoaneurysm but promotes dissection in Apoe-deficient mice.JCI insight · 2022Article
- Uncertainty quantification in subject-specific estimation of local vessel mechanical properties.International journal for numerical methods in biomedical engineering · 2021Article
- Translating mouse models of abdominal aortic aneurysm to the translational needs of vascular surgery.JVS-vascular science · 2021Review
- Predictive modelling of thrombus formation in diabetic retinal microaneurysms.Royal Society open science · 2020Article
- Multimodality Imaging-Based Characterization of Regional Material Properties in a Murine Model of Aortic Dissection.Scientific reports · 2020Article
- Recent Advances in Biomechanical Characterization of Thoracic Aortic Aneurysms.Frontiers in cardiovascular medicine · 2020Review
- Computational Hemodynamic Modeling of Arterial Aneurysms: A Mini-Review.Frontiers in physiology · 2020Review
- Early Morphofunctional Changes in AngII-Infused Mice Contribute to Regional Onset of Aortic Aneurysm and Dissection.Journal of vascular research · 2020Article
- Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions.Journal of visualized experiments : JoVE · 2019Article
- Biomechanical characterization of murine pulmonary arteries.Journal of biomechanics · 2019Article
- Assessing structural and functional response of murine vasculature to acute β-adrenergic stimulationInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2019Article
- After 50 Years of Heart Transplants: What Does the Next 50 Years Hold for Cardiovascular Medicine? A Perspective From the International Society for Applied Cardiovascular Biology.Frontiers in cardiovascular medicine · 2019Article
- Review
- Early pathological characterization of murine dissecting abdominal aortic aneurysms.APL bioengineering · 2018Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
A multi-modality imaging-based modeling approach was used to study complex unsteady hemodynamics and lesion growth in a dissecting abdominal aortic aneurysm model. We combined in vivo ultrasound (geometry and flow) and in vitro optical coherence tomography(OCT) (geometry) to obtain the high resolution needed to construct detailed hemodynamic simulations over large portions of the murine vasculature, which include fine geometric complexities. We illustrate this approach for a spectrum of dissecting abdominal aortic aneurysms induced in male apolipoprotein E-null mice by high-dose angiotensin II infusion. In vivo morphological and hemodynamic data provide information on volumetric lesion growth and changes in blood flow dynamics, respectively, occurring from the day of initial aortic expansion. We validated the associated computational models by comparing results on time-varying outlet flows and vortical structures within the lesions. Three out of four lesions exhibited abrupt formation of thrombus, though different in size. We determined that a lesion without thrombus formed with a thickened vessel wall, which was resolvable by OCT and histology. We attribute differences in final sizes and compositions of these lesions to the different computed flow and vortical structures we obtained in our mouse-specific fluid dynamic models. Differences in morphology and hemodynamics play crucial roles in determining the evolution of dissecting abdominal aortic aneurysms. Coupled high resolution in vivo and in vitro imaging approaches provide much-improved geometric models for hemodynamic simulations. Our imaging-based computational findings suggest a link between perturbations in hemodynamic metrics and aneurysmal disease heterogeneity.
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