ArticleGenes, brain, and behavior2017
Reduced levels of Cacna1c attenuate mesolimbic dopamine system function.
Open access · bronzeAbstract read
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Article in Genes, brain, and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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0cells of the map it votes in
21citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
What it found
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- L-type calcium channel blockade attenuates the anxiogenic-like effects of cocaine abstinence in female and male rats.Neuroscience · 2025Article
- The central role of microglia in major depressive disorder and its potential as a therapeutic target.Frontiers in behavioral neuroscience · 2025Review
- L-type calcium channel regulation of depression, anxiety and anhedonia-related behavioral phenotypes following chronic stress exposure.Neuropharmacology · 2024Article
- Differential genetic expression within reward-specific ensembles in mice.bioRxiv : the preprint server for biology · 2024Article
- L-type calcium channel regulation of dopamine activity in the ventral tegmental area to nucleus accumbens pathway: Implications for substance use, mood disorders and co-morbidities.Neuropharmacology · 2023Review
- Rats chirp with their mouth full: During an experimental meal, adult male Wistar rats emitted flat ultrasonic vocalisations upon feeding.Frontiers in behavioral neuroscience · 2023Article
- CACNA1C-Related Channelopathies.Handbook of experimental pharmacology · 2023Review
- Rare variants implicate NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder.Molecular psychiatry · 2022Article
- Review
- Calcium imaging reveals depressive- and manic-phase-specific brain neural activity patterns in a murine model of bipolar disorder: a pilot study.Translational psychiatry · 2021Article
- Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by hemizygosity of the psychiatric risk gene Cacna1c.Molecular psychiatry · 2021Article
- Cocaine- and stress-primed reinstatement of drug-associated memories elicit differential behavioral and frontostriatal circuit activity patterns via recruitment of L-type CaMolecular psychiatry · 2020Article
- Cacna1c Hemizygosity Results in Aberrant Fear Conditioning to Neutral Stimuli.Schizophrenia bulletin · 2020Article
- Dopamine Receptor Subtypes, Physiology and Pharmacology: New Ligands and Concepts in Schizophrenia.Frontiers in pharmacology · 2020Review
- How obsessive-compulsive and bipolar disorders meet each other? An integrative gene-based enrichment approach.Annals of general psychiatry · 2020Review
- Potentially repurposable drugs for schizophrenia identified from its interactome.Scientific reports · 2019Article
- Aetiology of bipolar disorder: contribution of the L-type voltage-gated calcium channels.General psychiatry · 2019Article
- Article
- Antipsychotic Drug Responsiveness and Dopamine Receptor Signaling; Old Players and New Prospects.Frontiers in psychiatry · 2018Review
- Downregulation of the psychiatric susceptibility geneCell death discovery · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
C E TerrillionDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
D T DaoDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
R CachopeDepartment of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
M K LoboDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
A C PucheProgram in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, USA.
J F CheerDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
T D GouldDepartment of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
University of Maryland, Baltimore · US
Funding
INTERDISCIPLINARY TRAINING PROGRAM IN NEUROSCIENCEST32MH015330 · NIMH · JOHNS HOPKINS UNIVERSITY · PI MARGOLIS, RUSSELL L · 1985 to 2024
$6.2MCocaine-induced mitochondrial mechanisms and molecular mediators in reward circuitryR01DA038613 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LOBO, MARY KAY · 2014 to 2025
$4.9MThe neurocircuitry of depression: Molecular and Cell Subtype MechanismsR01MH106500 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI LOBO, MARY KAY · 2015 to 2024
$4.5MEnduring Consequences of Adolescent Cannabinoid and Methylphenidate ExposureR01DA042595 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI CHEER, JOSEPH F · 2016 to 2020
$2.0MCannabinoid Receptor Mechanisms in Accumbal Encoding of Extinction LearningR01DA025890 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI CHEER, JOSEPH F · 2008 to 2012
$1.3MAn Upright Multiphoton Microscope for an Established Core Imaging FacilityS10OD010352 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI BLANPIED, THOMAS A · 2012 to 2012
$600kA Zeiss Duo Confocal Microscope for Shared Imaging FacilityS10RR024548 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI BLANPIED, THOMAS A · 2008 to 2008
$500kRegulatory Role of CACNA1C Intronic DNA Variation Relevant to Psychiatric DiseaseR21MH103847 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI CHANG, YEN PEI CHRISTY, GOULD, TODD D · 2014 to 2015
$422kNCRR NIH HHS S10 RR024548NIDA NIH HHS R01 DA025890NIDA NIH HHS R01 DA038613NIDA NIH HHS R01 DA042595NIH HHS S10 OD010352NIMH NIH HHS L30 MH091729NIMH NIH HHS R01 MH106500NIMH NIH HHS R21 MH103847NIMH NIH HHS T32 MH015330
Abstract
Genetic variation in CACNA1C, which codes for the L-type calcium channel (LTCC) Ca
Indexed as
AnimalsCalcium Channel BlockersCalcium Channels, L-TypeCentral Nervous System SensitizationDopamineDopamine Plasma Membrane Transport ProteinsDopamine Uptake InhibitorsFemaleLocomotionMaleMiceMice, Inbred C57BLNimodipineNucleus AccumbensPiperazinesVentral Tegmental AreaCACNA1C protein, mouseCalcium Channel BlockersCalcium Channels, L-TypeDopamineDopamine Plasma Membrane Transport ProteinsDopamine Uptake InhibitorsNimodipinePiperazinesvanoxerineBehaviorbipolar disorderCACNA1Cdepressiondopaminefast-scan cyclic voltammetrynucleus accumbensschizophreniasensitizationventral tegmental area
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.