Evidence map›Paper›PMID 28186685›Full record

ReviewStem cells translational medicine2017

Concise Review: Fat and Furious: Harnessing the Full Potential of Adipose-Derived Stromal Vascular Fraction.

Jordan A Dykstra, Tiffany Facile, Ryan J Patrick, Kevin R Francis, Samuel Milanovich, Jill M Weimer, Daniel J Kota

Abstract readReview
In one paragraph

Review in Stem cells translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed.

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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jordan A DykstraChildren's Health Research Center, Sanford Research, Sioux Falls, South Dakota, USA.
Tiffany FacileChildren's Health Research Center, Sanford Research, Sioux Falls, South Dakota, USA.
Ryan J PatrickChildren's Health Research Center, Sanford Research, Sioux Falls, South Dakota, USA.
Kevin R FrancisChildren's Health Research Center, Sanford Research, Sioux Falls, South Dakota, USA.
Samuel MilanovichChildren's Health Research Center, Sanford Research, Sioux Falls, South Dakota, USA.
Jill M WeimerChildren's Health Research Center, Sanford Research, Sioux Falls, South Dakota, USA.
Daniel J KotaChildren's Health Research Center, Sanford Research, Sioux Falls, South Dakota, USA.

Funding

Yeast 2 HybridP20GM103620 · NIGMS · SANFORD RESEARCH/USD · PI ROUX, KYLE J · 2013 to 2023
$24.2M
The Impact of PD-1 Inhibition on Immune-Response to ChemoradiotherapyP20GM103548 · NIGMS · SANFORD RESEARCH/USD · PI MISKIMINS, W KEITH · 2012 to 2020
$20.8M
Novel mechanisms for distal transport in developing and mature neuronsR01NS082283 · NINDS · SANFORD RESEARCH/USD · PI WEIMER, JILL M · 2014 to 2018
$1.9M
NIGMS NIH HHS P20 GM103548NIGMS NIH HHS P20 GM103620NINDS NIH HHS R01 NS082283
6 · The paper itself

Abstract

Due to their capacity to self-renew, proliferate and generate multi-lineage cells, adult-derived stem cells offer great potential for use in regenerative therapies to stop and/or reverse degenerative diseases such as diabetes, heart failure, Alzheimer's disease and others. However, these subsets of cells can be isolated from different niches, each with differing potential for therapeutic applications. The stromal vascular fraction (SVF), a stem cell enriched and adipose-derived cell population, has garnered interest as a therapeutic in regenerative medicine due to its ability to secrete paracrine factors that accelerate endogenous repair, ease of accessibility and lack of identified major adverse effects. Thus, one can easily understand the rush to employ adipose-derived SVF to treat human disease. Perhaps faster than any other cell preparation, SVF is making its way to clinics worldwide, while critical preclinical research needed to establish SVF safety, efficacy and optimal, standardized clinical procedures are underway. Here, we will provide an overview of the current knowledge driving this phenomenon, its regulatory issues and existing studies, and propose potential unmapped applications. Stem Cells Translational Medicine 2017;6:1096-1108.

Indexed as

AdipocytesAdipose TissueAnimalsHumansMesenchymal Stem CellsRegenerative MedicineStem CellsStem Cell TransplantationAdiposeAdult stem cellsAutologous stem cell transplantationCellular therapyClinical trialsMesenchymal stem cells

Identifiers

PMID28186685
PMCPMC5388064

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.