Trial reportJournal of veterinary internal medicine2017
Efficacy of a Probiotic-Prebiotic Supplement on Incidence of Diarrhea in a Dog Shelter: A Randomized, Double-Blind, Placebo-Controlled Trial.
Trial report in Journal of veterinary internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical effect of probiotics in prevention or treatment of gastrointestinal disease in dogs: A systematic review.Journal of veterinary internal medicine · 2019Pooled it
- Randomised controlled trial finds no evidence that a synbiotic improves health in assistance dog puppies.The Veterinary record · 2026Article
- Lactobacillus salivary LSbg3 is a Potential Food Probiotic Having Excellent Anti-pathogen Effect That Might Improve Antibiotic-Resistant Diarrhea in Dogs.Probiotics and antimicrobial proteins · 2026Article
- Systematic Review and Meta-Analysis of Quality Claims Associated with Fresh Pet Food: Evaluating Scientific Evidence for Additives, Ingredient Quality, and Effects of Processing in Pet Nutrition.Animals : an open access journal from MDPI · 2025Review
- The Role of Probiotics in Enhancing Animal Health: Mechanisms, Benefits, and Applications in Livestock and Companion Animals.Animals : an open access journal from MDPI · 2025Review
- Nutraceuticals, Social Interaction, and Psychophysiological Influence on Pet Health and Well-Being: Focus on Dogs and Cats.Veterinary sciences · 2025Review
- Use of biotics in animals: impact on nutrition, health, and food production.Journal of animal science · 2025Review
- The Function of Probiotics and Prebiotics on Canine Intestinal Health and Their Evaluation Criteria.Microorganisms · 2024Review
- Influence of dietary supplementation with newVeterinary world · 2023Article
- Alterations in Healthy Adult Canine Faecal Microbiome and Selected Metabolites as a Result of Feeding a Commercial Complete Synbiotic Diet withAnimals : an open access journal from MDPI · 2022Article
- The effect of photobiomodulation therapy on the management of chronic idiopathic large-bowel diarrhea in dogs.Lasers in medical science · 2022Article
- Effect of probiotics on diversity and function of gut microbiota in Moschus berezovskii.Archives of microbiology · 2021Article
- A survey on the prevalence of diarrhea in a Portuguese population of police working dogs.BMC veterinary research · 2021Article
- The microbiota of healthy dogs demonstrates individualized responses to synbiotic supplementation in a randomized controlled trial.Animal microbiome · 2021Article
- Modulation of Gut Microbiota and Immune System by Probiotics, Pre-biotics, and Post-biotics.Frontiers in nutrition · 2021Review
- State-of-the-Art of the Nutritional Alternatives to the Use of Antibiotics in Humans and Monogastric Animals.Animals : an open access journal from MDPI · 2020Review
- Randomized, controlled, crossover trial of prevention of antibiotic-induced gastrointestinal signs using a synbiotic mixture in healthy research dogs.Journal of veterinary internal medicine · 2019Article
- Efficacy of an orally administered anti-diarrheal probiotic paste (Pro-Kolin Advanced) in dogs with acute diarrhea: A randomized, placebo-controlled, double-blinded clinical study.Journal of veterinary internal medicine · 2019Article
- Engineering the microbiome for animal health and conservation.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- Pharmaceutical Prescription in Canine Acute Diarrhoea: A Longitudinal Electronic Health Record Analysis of First Opinion Veterinary Practices.Frontiers in veterinary science · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiarrhea is the most frequent morbidity affecting kenneled dogs in animal shelters. Diarrhea impacts animal welfare and the finances of the shelter as they must treat, clean, and house affected animals until recovered. HYPOTHESIS/
objectivesSupplementing dogs entering an animal shelter with a probiotic-prebiotic, known as a synbiotic, will decrease the incidence of diarrhea. ANIMALS: Seven hundred and seventy-three dogs entering an animal shelter in the United Kingdom.
methodsA prospective double-blind, randomized, placebo-controlled trial.
resultsStatistical difference was found between the groups across 3 measures of diarrhea incidence. First, the mean percentage of scored days per dog that were scored as diarrhea throughout their stay was 2.0% in the synbiotic group and 3.2% in the placebo group (P = .0022). Second, the occurrence of diarrhea within the first 14 days' stay was 18.8% in the synbiotic product group and 27.2% in the placebo group (P = .0008). Third, the occurrence of ≥2 consecutive days of diarrhea within the first 14 days' stay was 4.6% in the synbiotic product group and 8.0% in the placebo group (P = .0300). CONCLUSIONS AND CLINICAL IMPORTANCE: Supplementing healthy dogs entering an animal shelter with a synbiotic supplement significantly decreased the incidence of diarrhea in this trial. Animal shelters can use synbiotic supplements to improve animal welfare and decrease costs involved in cleaning and housing animals as well as potentially decreasing veterinary intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.