ArticleThe ISME journal2017
Underlying mechanisms for syntrophic metabolism of essential enzyme cofactors in microbial communities.
Article in The ISME journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed.
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- The oral maternal microbiome plays a role in the development of cleft lip and palate condition in children.PeerJ · 2026Article
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- Evolutionary history and association with seaweeds shape the genomes and metabolisms of marine bacteria.mSphere · 2025Article
- Candidate Phyla Radiation (CPR) bacteria from hyperalkaline ecosystems provide novel insight into their symbiotic lifestyle and ecological implications.Microbiome · 2025Article
- Niche formation and metabolic interactions contribute to stable diversity in a spatially structured cyanobacterial community.The ISME journal · 2025Article
- Unveiling the significance of prokaryotic composition from ferromanganese crusts regarding the interlink between cobalt and vitamin BFrontiers in microbiology · 2025Article
- Reversing metabolic dysregulation in farnesoid X receptor knockout mice via gut microbiota modulation.PloS one · 2025Article
- Microbially-produced folate forms support the growth of Roseburia intestinalis but not its competitive fitness in fecal batch fermentations.BMC microbiology · 2024Article
- Taxonomic and functional metagenomic assessment of a Dolichospermum bloom in a large and deep lake south of the Alps.FEMS microbiology ecology · 2024Article
- Viral communities in a pH>10 serpentinite-like environment: insight into diversity and potential roles in modulating the microbiomes by bioactive vitamin BApplied and environmental microbiology · 2024Article
- Epiphytic Bacterial Community Analysis ofMicroorganisms · 2024Article
- Investigating oral microbiome profiles in patients with cleft lip and palate compared with the healthy control.BMC oral health · 2024Article
- Genome-scale community modelling reveals conserved metabolic cross-feedings in epipelagic bacterioplankton communities.Nature communications · 2024Article
- Bidirectional ATP-driven transport of cobalamin by the mycobacterial ABC transporter BacA.Nature communications · 2024Article
- Rhizobacterial syntrophy between a helper and a beneficiary promotes tomato plant health.The ISME journal · 2024Article
- A comprehensive overview of the Chloroflexota community in wastewater treatment plants worldwide.mSystems · 2023Review
1 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many microorganisms are unable to synthesize essential B vitamin-related enzyme cofactors de novo. The underlying mechanisms by which such microbes survive in multi-species communities are largely unknown. We previously reported the near-complete genome sequence of two ~18-member unicyanobacterial microbial consortia that maintain stable membership on defined medium lacking vitamins. Here we have used genome analysis and growth studies on isolates derived from the consortia to reconstruct pathways for biogenesis of eight essential cofactors and predict cofactor usage and precursor exchange in these communities. Our analyses revealed that all but the two Halomonas and cyanobacterial community members were auxotrophic for at least one cofactor. We also observed a mosaic distribution of salvage routes for a variety of cofactor precursors, including those produced by photolysis. Potentially bidirectional transporters were observed to be preferentially in prototrophs, suggesting a mechanism for controlled precursor release. Furthermore, we found that Halomonas sp. do not require cobalamin nor control its synthesis, supporting the hypothesis that they overproduce and export vitamins. Collectively, these observations suggest that the consortia rely on syntrophic metabolism of cofactors as a survival strategy for optimization of metabolic exchange within a shared pool of micronutrients.
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