Evidence map›Paper›PMID 28186489›Full record

ArticleeLife2017

Folding behavior of a T-shaped, ribosome-binding translation enhancer implicated in a wide-spread conformational switch.

My-Tra Le, Wojciech K Kasprzak, Taejin Kim, Feng Gao, Megan Yl Young, Xuefeng Yuan, Bruce A Shapiro, Joonil Seog, Anne E Simon

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Translational Control in Virus-Infected Cells.Cold Spring Harbor perspectives in biology · 2019
    Review
  9. Article
  10. Article
  11. Article
  12. Non-canonical Translation in Plant RNA Viruses.Frontiers in plant science · 2017
    Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

My-Tra LeDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, United States.
Wojciech K KasprzakBasic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, United States.
Taejin KimRNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, United States.
Feng GaoDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, United States.
Megan Yl YoungDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, United States.
Xuefeng YuanDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, United States.
Bruce A ShapiroRNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, United States.
Joonil SeogDepartment of Materials Science and Engineering, University of Maryland, College Park, United States.
Anne E SimonDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, United States.ORCID 0000-0001-6121-0704
University of Maryland, College Park · USNational Cancer Institute · USLeidos (United States) · US

Funding

Computational Approaches for RNA StructureFunction DeterminationZIABC008382 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SHAPIRO, BRUCE · 2009 to 2021
$5.8M
Training Program in Cell & Molecular BiologyT32GM080201 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI DELWICHE, CHARLES F · 2009 to 2019
$1.6M
New Paradigms for Ribosome Recoding in (+)Strand VirusesR21AI117882 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI SIMON, ANNE ELIZABETH · 2015 to 2016
$410k
CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENIAID NIH HHS R21 AI117882NIGMS NIH HHS T32 GM080201
6 · The paper itself

Abstract

Turnip crinkle virus contains a T-shaped, ribosome-binding, translation enhancer (TSS) in its 3'UTR that serves as a hub for interactions throughout the region. The viral RNA-dependent RNA polymerase (RdRp) causes the TSS/surrounding region to undergo a conformational shift postulated to inhibit translation. Using optical tweezers (OT) and steered molecular dynamic simulations (SMD), we found that the unusual stability of pseudoknotted element H4a/Ψ

Indexed as

Nucleic Acid ConformationProtein BiosynthesisCarmovirusDNA Mutational AnalysisMolecular Dynamics SimulationRibosomesRNA-Dependent RNA PolymeraseRNA, ViralRNA-Dependent RNA PolymeraseRNA, Viralbiophysicsmolecular dynamicsoptical tweezersRNA structureRNA virusstructural biologyTurnip crinkle virus

Identifiers

PMID28186489
PMCPMC5336357
OpenAlexW2586947288

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.