Evidence map›Paper›PMID 28186199›Full record

ArticleScientific reports2017

Ubiquitination mediates Kv1.3 endocytosis as a mechanism for protein kinase C-dependent modulation.

Ramón Martínez-Mármol, Katarzyna Styrczewska, Mireia Pérez-Verdaguer, Albert Vallejo-Gracia, Núria Comes, Alexander Sorkin, Antonio Felipe

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Identification of Novel Kv1.3 Channel-Interacting Proteins Using Proximity Labelling in T-Cells.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Insights of Endocytosis Signaling in Health and Disease.International journal of molecular sciences · 2023
    Review
  7. Review
  8. Palmitoylation of Voltage-Gated Ion Channels.International journal of molecular sciences · 2022
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Dlg1 Maintains Dendritic Cell Function by Securing Voltage-Gated KJournal of immunology (Baltimore, Md. : 1950) · 2019
    Article
  15. Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Ramón Martínez-MármolMolecular Physiology laboratory, Departament de Bioquímica i Biomedicna Molecular, Institut de Biomedicina (IBUB), Universitat de Barcelona, 08028 Barcelona, Spain.
Katarzyna StyrczewskaMolecular Physiology laboratory, Departament de Bioquímica i Biomedicna Molecular, Institut de Biomedicina (IBUB), Universitat de Barcelona, 08028 Barcelona, Spain.
Mireia Pérez-VerdaguerMolecular Physiology laboratory, Departament de Bioquímica i Biomedicna Molecular, Institut de Biomedicina (IBUB), Universitat de Barcelona, 08028 Barcelona, Spain.
Albert Vallejo-GraciaMolecular Physiology laboratory, Departament de Bioquímica i Biomedicna Molecular, Institut de Biomedicina (IBUB), Universitat de Barcelona, 08028 Barcelona, Spain.
Núria ComesMolecular Physiology laboratory, Departament de Bioquímica i Biomedicna Molecular, Institut de Biomedicina (IBUB), Universitat de Barcelona, 08028 Barcelona, Spain.
Alexander SorkinDepartment of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA.
Antonio FelipeMolecular Physiology laboratory, Departament de Bioquímica i Biomedicna Molecular, Institut de Biomedicina (IBUB), Universitat de Barcelona, 08028 Barcelona, Spain.
Universitat de Barcelona · ESUniversity of Pittsburgh · US

Funding

Regulation of Dopamine Transporter by TraffickingR01DA014204 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALEXANDER D SORKIN · 2001 to 2026
$8.3M
PATHOGENESIS OF CANCER--ROLE OF EGF RECEPTOR ENDOCYTOSISR01CA089151 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SORKIN, ALEXANDER D · 2001 to 2023
$6.9M
NCI NIH HHS R01 CA089151NIDA NIH HHS R01 DA014204
6 · The paper itself

Abstract

The voltage-dependent potassium channel Kv1.3 plays essential physiological functions in the immune system. Kv1.3, regulating the membrane potential, facilitates downstream Ca

Indexed as

EndocytosisUbiquitinationAdenosineAnimalsClathrinDendritic CellsDisks Large Homolog 4 ProteinDown-RegulationHEK293 CellsHumansKv1.3 Potassium ChannelLipopolysaccharidesLysosomesMacrophage ActivationMembrane MicrodomainsMiceAdenosineClathrinDisks Large Homolog 4 ProteinDLG4 protein, humanKv1.3 Potassium ChannelLipopolysaccharidesNedd4 protein, humanNedd4 Ubiquitin Protein LigasesProtein Kinase CTetradecanoylphorbol Acetate

Identifiers

PMID28186199
PMCPMC5301257
OpenAlexW2587327638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.