ArticleScientific reports2017
Factors associated with aberrant imprint methylation and oligozoospermia.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic review of associations of polychlorinated biphenyl (PCB) exposure with declining semen quality in support of the derivation of reference doses for mixture risk assessments.Environmental health : a global access science source · 2022Pooled it
- Advanced paternal age is associated with an increased risk of spontaneous miscarriage: a systematic review and meta-analysis.Human reproduction update · 2020Pooled it
- Machine learning-based prediction of IVF/ICSI outcomes in male factor infertility highlighting couple-level BMI.Frontiers in endocrinology · 2026Article
- Beyond Genes: Mechanistic and Epidemiological Insights into Paternal Environmental Influence on Offspring Health.Current environmental health reports · 2025Review
- Article
- Global 5mC and 5hmC DNA Levels in Human Sperm Subpopulations with Differentially Protaminated Chromatin in Normo- and Oligoasthenozoospermic Males.International journal of molecular sciences · 2022Article
- Contemporary Use of ICSI and Epigenetic Risks to Future Generations.Journal of clinical medicine · 2022Review
- Microenvironment for spermatogenesis and sperm maturation.Histochemistry and cell biology · 2022Review
- Genetic counseling prior to assisted reproductive technology.Reproductive medicine and biology · 2021Review
- Investigating the Role of the microRNA-34/449 Family in Male Infertility: A Critical Analysis and Review of the Literature.Frontiers in endocrinology · 2021Review
- High-resolution analyses of human sperm dynamic methylome reveal thousands of novel age-related epigenetic alterations.Clinical epigenetics · 2020Article
- In the human sperm nucleus, nucleosomes form spatially restricted domains consistent with programmed nucleosome positioning.Biology open · 2019Article
- Temporal Dynamics of DNA Methylation Patterns in Response to Rearing Juvenile Steelhead (Genes · 2019Article
- Methylation at cg05575921 of a smoking-related gene (AHRR) in non-smoking Taiwanese adults residing in areas with different PMClinical epigenetics · 2019Article
- Association of Sperm Methylation atFrontiers in genetics · 2019Article
- Silencing of retrotransposon-derived imprinted gene RTL1 is the main cause for postimplantational failures in mammalian cloning.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Sperm imprinting integrity in seminoma patients?Clinical epigenetics · 2018Article
- Loss of Imprinting ofInternational journal of molecular sciences · 2018Article
- A multi-scale analysis of bull sperm methylome revealed both species peculiarities and conserved tissue-specific features.BMC genomics · 2018Article
- Passing experiences on to future generations: endocrine disruptors and transgenerational inheritance of epimutations in brain and sperm.Epigenetics · 2018Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disturbingly, the number of patients with oligozoospermia (low sperm count) has been gradually increasing in industrialized countries. Epigenetic alterations are believed to be involved in this condition. Recent studies have clarified that intrinsic and extrinsic factors can induce epigenetic transgenerational phenotypes through apparent reprogramming of the male germ line. Here we examined DNA methylation levels of 22 human imprinted loci in a total of 221 purified sperm samples from infertile couples and found methylation alterations in 24.8% of the patients. Structural equation model suggested that the cause of imprint methylation errors in sperm might have been environmental factors. More specifically, aberrant methylation and a particular lifestyle (current smoking, excess consumption of carbonated drinks) were associated with severe oligozoospermia, while aging probably affected this pathology indirectly through the accumulation of PCB in the patients. Next we examined the pregnancy outcomes for patients when the sperm had abnormal imprint methylation. The live-birth rate decreased and the miscarriage rate increased with the methylation errors. Our research will be useful for the prevention of methylation errors in sperm from infertile men, and sperm with normal imprint methylation might increase the safety of assisted reproduction technology (ART) by reducing methylation-induced diseases of children conceived via ART.
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