ArticleScientific reports2017
Multilocus sequence analyses reveal extensive diversity and multiple origins of fluconazole resistance in Candida tropicalis from tropical China.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Pediatric candidemia epidemiology and antifungal susceptibility profiles reported by the ISPED program in China, 2016-2024.Antimicrobial agents and chemotherapy · 2026Article
- Article
- Genotypic Analysis of Candida tropicalis Clinical Isolates From Korea via Multilocus Sequence Typing.MicrobiologyOpen · 2025Article
- Clinical and Molecular Epidemiological Characteristics of 26 Bloodstream Infection Cases Caused by Candida tropicalis.Mycopathologia · 2025Article
- Prevalence, drug resistance and genetic diversity ofMycology · 2025Article
- Whole Genome Sequencing Shows Genetic Diversity, as Well as Clonal Complex and Gene Polymorphisms Associated with Fluconazole Non-Susceptible Isolates ofJournal of fungi (Basel, Switzerland) · 2022Article
- Extensive Diversity and Prevalent Fluconazole Resistance among Environmental Yeasts from Tropical China.Genes · 2022Article
- Historical Differentiation and Recent Hybridization in Natural Populations of the Nematode-Trapping FungusMicroorganisms · 2021Article
- Species Diversity and Antifungal Susceptibilities of Oral Yeasts from Patients with Head and Neck Cancer.Infection and drug resistance · 2021Article
- Molecular epidemiology of Candida tropicalis isolated from urogenital tract infections.MicrobiologyOpen · 2020Article
- Multilocus Sequence Typing Reveals Clonality of Fluconazole-NonsusceptibleFrontiers in microbiology · 2020Article
- An Association of an eBURST Group With Triazole Resistance ofFrontiers in microbiology · 2020Article
- Clonality of Fluconazole-Nonsusceptible Candida tropicalis in Bloodstream Infections, Taiwan, 2011-2017.Emerging infectious diseases · 2019Observational
- A Predominance of Clade 17Frontiers in microbiology · 2019Article
- Analyses of the Global Multilocus Genotypes of the Human Pathogenic YeastFrontiers in microbiology · 2019Article
- Multilocus sequence typing of Candida albicans isolates from the oral cavities of patients undergoing haemodialysis.Scientific reports · 2018Article
- Development of Echinocandin Resistance in Candida tropicalis following Short-Term Exposure to Caspofungin for Empiric Therapy.Antimicrobial agents and chemotherapy · 2018Article
- Multilocus Sequence Typing Reveals a New Cluster of Closely RelatedFrontiers in microbiology · 2018Article
- Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Candida tropicalis is among the most prevalent human pathogenic yeast species, second only to C. albicans in certain geographic regions such as East Asia and Brazil. However, compared to C. albicans, relatively little is known about the patterns of genetic variation in C. tropicalis. This study analyzed the genetic diversity and relationships among isolates of C. tropicalis from the southern Chinese island of Hainan. A total of 116 isolates were obtained from seven geographic regions located across the Island. For each isolate, a total of 2677 bp from six gene loci were sequenced and 79 (2.96%) polymorphic nucleotide sites were found in our sample. Comparisons with strains reported from other parts of the world identified significant novel diversities in Hainan, including an average of six novel sequences (with a range 1 to 14) per locus and 80 novel diploid sequence types. Most of the genetic variation was found within individual strains and there was abundant evidence for gene flow among the seven geographic locations within Hainan. Interestingly, our analyses identified no significant correlation between the diploid sequence types at the six loci and fluconazole susceptibility, consistent with multiple origins of fluconazole resistance in the Hainan population of C. tropicalis.
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