Evidence map›Paper›PMID 28186139›Full record

ArticleScientific reports2017

Dysregulated autophagy increased melanocyte sensitivity to H

Yuanmin He, Shuli Li, Weigang Zhang, Wei Dai, Tingting Cui, Gang Wang, Tianwen Gao, Chunying Li

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 115 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Genetics of Vitiligo: A Review.Clinical, cosmetic and investigational dermatology · 2026
    Review
  5. Article
  6. Review
  7. Emerging Roles of Ferroptosis in Skin Pathophysiology.The Journal of investigative dermatology · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Reactive Oxygen Species and Antioxidant System in Selected Skin Disorders.The Malaysian journal of medical sciences : MJMS · 2023
    Review
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yuanmin HeDepartment of Dermatology, Xijing hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Shuli LiDepartment of Dermatology, Xijing hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Weigang ZhangDepartment of Dermatology, Xijing hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Wei DaiDepartment of Dermatology, Xijing hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Tingting CuiDepartment of Dermatology, Xijing hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Gang WangDepartment of Dermatology, Xijing hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Tianwen GaoDepartment of Dermatology, Xijing hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Chunying LiDepartment of Dermatology, Xijing hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Air Force Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In vitiligo, melanocytes are particularly vulnerable to oxidative stress owing to the pro-oxidant state generated during melanin synthesis and to the genetic antioxidant defects. Autophagy is a controlled self-digestion process which can protect cells against oxidative damage. However, the exact role of autophagy in vitiligo melanocytes in response to oxidative stress and the mechanism involved are still not clear. To determine the implications of autophagy for melanocyte survival in response to oxidative stress, we first detected the autophagic flux in normal melanocytes exposure to H

Indexed as

ApoptosisAutophagyCytoprotectionHumansHydrogen PeroxideMelanocytesMembrane Potential, MitochondrialModels, BiologicalNF-E2-Related Factor 2Oxidative StressSequestosome-1 ProteinSignal TransductionUp-RegulationVitiligoHydrogen PeroxideNF-E2-Related Factor 2Sequestosome-1 ProteinSQSTM1 protein, human

Identifiers

PMID28186139
PMCPMC5301258
OpenAlexW2587181665

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.