Evidence map›Paper›PMID 28186098›Full record

ArticleInternational journal of obesity (2005)2017

Postnatal height and adiposity gain, childhood blood pressure and prehypertension risk in an Asian birth cohort.

I M Aris, J Y Bernard, L-W Chen, M T Tint, W Y Lim, S E Soh, S-M Saw, L P-C Shek, K M Godfrey, P D Gluckman and 4 more

Open access · greenAbstract read
In one paragraph

Article in International journal of obesity (2005), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Cardiometabolic Profile of Different Body Composition Phenotypes in Children.The Journal of clinical endocrinology and metabolism · 2021
    Article
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  10. Review
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  13. Article
  14. Analysis of 'sensitive' periods of fetal and child growth.International journal of epidemiology · 2019
    Observational
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  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 4 countries.

I M ArisSingapore Institute for Clinical Sciences, Agency for Science, Technology, Singapore, Singapore.
J Y BernardSingapore Institute for Clinical Sciences, Agency for Science, Technology, Singapore, Singapore.
L-W ChenDepartment of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
M T TintDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
W Y LimSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
S E SohSingapore Institute for Clinical Sciences, Agency for Science, Technology, Singapore, Singapore.
S-M SawSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
L P-C ShekDepartment of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
K M GodfreyMRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, England, UK.
P D GluckmanSingapore Institute for Clinical Sciences, Agency for Science, Technology, Singapore, Singapore.
Y-S ChongSingapore Institute for Clinical Sciences, Agency for Science, Technology, Singapore, Singapore.
F YapDepartment of Pediatrics, KK Women's and Children's Hospital, Singapore, Singapore.
M S KramerDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Y S LeeSingapore Institute for Clinical Sciences, Agency for Science, Technology, Singapore, Singapore.
National University of Singapore · SGSingapore Institute for Clinical Sciences · SGDuke-NUS Medical School · SGMcGill University Health Centre · CAMRC Lifecourse Epidemiology Unit · GBNational University Health System · SG

Funding

Arthritis Research UK 17702British Heart Foundation RG/07/009/23120Department of Health SOUDIBRU-2008-1Medical Research Council G0400491Medical Research Council MC_U147585819Medical Research Council MC_U147585824Medical Research Council MC_U147585827Medical Research Council MC_UP_A620_1014Medical Research Council MC_UU_12011/1Medical Research Council MC_UU_12011/4
6 · The paper itself

Abstract

objectiveThere have been hypotheses that early life adiposity gain may influence blood pressure (BP) later in life. We examined associations between timing of height, body mass index (BMI) and adiposity gains in early life with BP at 48 months in an Asian pregnancy-birth cohort.

methodsIn 719 children, velocities for height, BMI and abdominal circumference (AC) were calculated at five intervals [0-3, 3-12, 12-24, 24-36 and 36-48 months]. Triceps (TS) and subscapular skinfold (SS) velocities were calculated between 0-18, 18-36 and 36-48 months. Systolic (SBP) and diastolic blood pressure (DBP) was measured at 48 months. Growth velocities at later periods were adjusted for growth velocities in preceding intervals, as well as measurements at birth.

resultsAfter adjusting for confounders and child height at BP measurement, each unit z-score gain in BMI, AC, TS and SS velocities at 36-48 months were associated with 2.3 (95% CI:1.6, 3.1), 2.1 (1.3, 2.8), 1.4 (0.6, 2.2) and 1.8 (1, 2.6) mmHg higher SBP respectively, and 0.9 (0.4, 1.4), 0.9 (0.4, 1.3), 0.6 (0.1, 1.1) and 0.8 (0.3, 1.3) mmHg higher DBP respectively. BMI and adiposity velocities (AC, TS or SS) at various intervals in the first 36 months however, were not associated with BP. Faster BMI, AC, TS and SS velocities, but not height, at 36-48 months were associated with 0.22 (0.15, 0.29), 0.17 (0.10, 0.24), 0.11 (0.04, 0.19) and 0.15 (0.08, 0.23) units higher SBP z-score respectively, and OR=1.46 (95% CI: 1.13-1.90), 1.49 (1.17-1.92), 1.45 (1.09-1.92) and 1.43 (1.09, 1.88) times higher risk of prehypertension/hypertension respectively at 48 months.

conclusionsOur results indicated that faster BMI and adiposity (AC, TS or SS) velocities only at the preceding interval before 48 months (36-48 months), but not at earlier intervals in the first 36 months, are predictive of BP and prehypertension/hypertension at 48 months.

Indexed as

Body HeightAdiposityAsian PeopleBlood PressureBody Mass IndexChild, PreschoolFemaleHumansHypertensionInfantInfant, NewbornMalePediatric ObesityPregnancyPrehypertensionProspective Studies

Identifiers

PMID28186098
PMCPMC5473468
OpenAlexW2587354972

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.