ArticleNanomedicine : nanotechnology, biology, and medicine2017
Twisting electrospun nanofiber fine strips into functional sutures for sustained co-delivery of gentamicin and silver.
Article in Nanomedicine : nanotechnology, biology, and medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 63 citations in OpenAlex.
- Fiber Technology in Drug Delivery and Pharmaceuticals.Current drug delivery · 2025Review
- Electrospun Drug-Loaded and Gene-Loaded Nanofibres: The Holy Grail of Glioblastoma Therapy?Pharmaceutics · 2023Review
- A review of current advancements for wound healing: Biomaterial applications and medical devices.Journal of biomedical materials research. Part B, Applied biomaterials · 2022Review
- Tissue Adhesives in Reconstructive and Aesthetic Surgery-Application of Silk Fibroin-Based Biomaterials.International journal of molecular sciences · 2022Review
- Electrospun Medical Sutures for Wound Healing: A Review.Polymers · 2022Review
- Nanofiber curvature with Rho GTPase activity increases mouse embryonic fibroblast random migration velocity.Integrative biology : quantitative biosciences from nano to macro · 2021Article
- Electrostatic flocking of salt-treated microfibers and nanofiber yarns for regenerative engineering.Materials today. Bio · 2021Article
- Engineering biomaterials to prevent post-operative infection and fibrosis.Drug delivery and translational research · 2021Review
- Encapsulation of Pharmaceutical and Nutraceutical Active Ingredients Using Electrospinning Processes.Nanomaterials (Basel, Switzerland) · 2021Review
- The Combined Use of Gentamicin and Silver Nitrate in Bone Cement for a Synergistic and Extended Antibiotic Action against Gram-Positive and Gram-Negative Bacteria.Materials (Basel, Switzerland) · 2021Article
- Multifunctional nanoplatforms co-delivering combinatorial dual-drug for eliminating cancer multidrug resistance.Theranostics · 2021Review
- New forms of electrospun nanofiber materials for biomedical applications.Journal of materials chemistry. B · 2020Review
- Mesenchymal stem cell-laden, personalized 3D scaffolds with controlled structure and fiber alignment promote diabetic wound healing.Acta biomaterialia · 2020Article
- Recent Advances in Tissue Adhesives for Clinical Medicine.Polymers · 2020Review
- Electrospun fibers and their application in drug controlled release, biological dressings, tissue repair, and enzyme immobilization.RSC advances · 2019Review
- Use of affinity allows anti-inflammatory and anti-microbial dual release that matches suture wound resolution.Journal of biomedical materials research. Part A · 2019Article
- Fabrication of injectable and superelastic nanofiber rectangle matrices ("peanuts") and their potential applications in hemostasis.Biomaterials · 2018Article
- Nanofiber-based sutures induce endogenous antimicrobial peptide.Nanomedicine (London, England) · 2017Article
- Recent advances in electrospun nanofibers for wound healing.Nanomedicine (London, England) · 2017Review
- Preparation of laminin/nidogen adsorbed urinary bladder decellularized materials via a mussel-inspired polydopamine coating for pelvic reconstruction.American journal of translational research · 2017Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Surgical site infections (SSIs) represent the most common nosocomial infection among surgical patients. In order to prevent SSIs in a sustained manner and lessen side effects, we developed a twisting method for generation of nanofiber-based sutures capable of simultaneous delivery of silver and gentamicin. The prepared sutures are composed of core-sheath nanofibers with gentamicin/pluronic F127 in the core and silver/PCL in the sheath produced by co-axial electrospinning. The diameters of obtained sutures range from ~80 μm to ~1.2 mm. The in vitro release profiles of silver and gentamicin exhibit an initial burst followed by a sustained release over 5 weeks. The co-encapsulated sutures were able to kill bacteria much more effectively than gentamicin or silver alone loaded nanofiber sutures, without showing obvious impact on proliferation and migration of dermal fibroblasts and keratinocytes. The gentamicin and silver co-loaded PCL nanofiber sutures may hold great potential for prevention of SSIs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.