Evidence map›Paper›PMID 28185790›Full record

ReviewTrends in molecular medicine2017

Immune Regulation of Antibody Access to Neuronal Tissues.

Akiko Iwasaki

Abstract readReview
In one paragraph

Review in Trends in molecular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Cell-to-Cell Signaling Networks at the Blood-Brain Barrier in Health and Disease.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. B cells in non-lymphoid tissues.Nature reviews. Immunology · 2025
    Review
  8. Article
  9. Article
  10. Therapeutic targeting of senescent cells in the CNS.Nature reviews. Drug discovery · 2024
    Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Akiko IwasakiHoward Hughes Medical Institute, Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. Electronic address: akiko.iwasaki@yale.edu.
Howard Hughes Medical Institute · US

Funding

Immunity to Genital Herpes Simplex-2R01AI054359 · NIAID · YALE UNIVERSITY · PI IWASAKI, AKIKO · 2004 to 2019
$5.2M
Molecular and Cellular Transport in MucusR01EB000487 · NIBIB · YALE UNIVERSITY · PI IWASAKI, AKIKO, SALTZMAN, W. MARK · 2002 to 2019
$5.0M
Innate antiviral defense against Vaginal transmission of ZIKA virusR21AI131284 · NIAID · YALE UNIVERSITY · PI IWASAKI, AKIKO · 2017 to 2018
$461k
Vaginally-delivered Nanoparticles for Prevention and Treatment of HSV-2 InfectionsR56AI125504 · NIAID · YALE UNIVERSITY · PI IWASAKI, AKIKO, SALTZMAN, W. MARK · 2016 to 2016
$386k
Restimulating memory T cell responses in elderly by a novel, live influenza vaccineR41AI120269 · NIAID · FLUGEN, INC. · PI BILSEL, PAMUK, IWASAKI, AKIKO · 2015 to 2015
$225k
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI054359NIAID NIH HHS R21 AI131284NIAID NIH HHS R41 AI120269NIAID NIH HHS R56 AI125504NIBIB NIH HHS R01 EB000487
6 · The paper itself

Abstract

This review highlights recent advances in how the innate and adaptive immune systems control the blood-brain barrier (BBB) and the blood-nerve barrier (BNB). Interferons and TAM receptors play key roles in innate immune control of the BBB. Cells of the adaptive immune system, particularly CD4

Indexed as

Adaptive ImmunityImmunity, InnateAnimalsAntibodiesBlood-Brain BarrierBlood-Nerve BarrierBrain NeoplasmsHumansImmunotherapyInterferonsNeurodegenerative DiseasesReceptor Protein-Tyrosine KinasesT-LymphocytesVirus DiseasesVirusesAntibodiesInterferonsReceptor Protein-Tyrosine Kinases

Identifiers

PMID28185790
PMCPMC5626569
OpenAlexW2587035337

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.