Evidence map›Paper›PMID 28185625›Full record

Trial reportThe Journal of pediatrics2017

Impact of Erythropoiesis-Stimulating Agents on Behavioral Measures in Children Born Preterm.

Jean R Lowe, Rebecca E Rieger, Natalia C Moss, Ronald A Yeo, Sarah Winter, Shrena Patel, John Phillips, Richard Campbell, Shawna Baker, Sean Gonzales and 1 more

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 10 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 4 pooled it
4.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00334737 phase2completednot on this map

A Randomized, Masked, Placebo Controlled Study to Assess the Safety and Efficacy of Darbepoetin Alfa Administered to Preterm Infants

TypeinterventionalSponsorUniversity of New MexicoRan2006 to 2014Enrolled102ConditionsInfant, NewbornArmsDarbepoetin Alfa Injection, erythropoietin alfa injection, sham injection
NCT01207778 completednot on this map

Brain Imaging and Developmental Follow up of Infants Treated With Erythropoietin

TypeobservationalSponsorUniversity of New MexicoRan2010 to 2020Enrolled77ConditionsPrematurity
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 4 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Review
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Jean R LoweDepartment of Pediatrics, University of New Mexico School of Medicine, Albuquerque, NM.
Rebecca E RiegerDepartment of Psychology, University of New Mexico, Albuquerque, NM.
Natalia C MossDepartment of Psychology, University of New Mexico, Albuquerque, NM.
Ronald A YeoDepartment of Psychology, University of New Mexico, Albuquerque, NM.
Sarah WinterDepartment of Pediatrics, University of Utah, Salt Lake City, UT.
Shrena PatelDepartment of Pediatrics, University of Utah, Salt Lake City, UT.
John PhillipsDepartment of Neurology, University of New Mexico, Albuquerque, NM.
Richard CampbellDepartment of Psychiatry, University of New Mexico, Albuquerque, NM.
Shawna BakerDepartment of Pediatrics, University of Utah, Salt Lake City, UT.
Sean GonzalesDepartment of Pediatrics, University of New Mexico School of Medicine, Albuquerque, NM.
Robin K OhlsDepartment of Pediatrics, University of New Mexico School of Medicine, Albuquerque, NM. Electronic address: rohls@salud.unm.edu.
University of New Mexico · USUniversity of Utah · US

Funding

University of New Mexico (UNM) Center for Brain Recovery and RepairP20GM109089 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI SHUTTLEWORTH, CLAUDE W · 2015 to 2024
$22.7M
University of Utah Center for Clinical and Translational ScienceUL1TR001067 · NCATS · UNIVERSITY OF UTAH · PI DERE, WILLARD H., HESS, RACHEL · 2013 to 2017
$19.8M
University of New Mexico Clinical and Translational Science CenterUL1TR000041 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI LARSON, RICHARD S · 2012 to 2014
$9.8M
Brain imaging and developmental follow-up of infants treated with erythropoietinR01HD059856 · NICHD · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI OHLS, ROBIN K · 2010 to 2014
$2.2M
NCATS NIH HHS UL1 TR000041NCATS NIH HHS UL1 TR001067NICHD NIH HHS R01 HD059856NIGMS NIH HHS P20 GM109089
6 · The paper itself

Abstract

objectiveTo evaluate the impact of erythropoiesis-stimulating agents (ESAs) administered during initial hospitalization and family demographic factors on behavior at 3.5-4 years of age. STUDY

designChildren were enrolled who had previously participated in a randomized study of ESAs (n = 35) or placebo (n = 14) in infants born preterm with birth weights of 500-1250 g. A term healthy control group (n = 22) also was recruited. Behavior was evaluated by parent report with the Behavioral Assessment System of Children-2. Principal component analyses identified 2 demographic factors, a Socioeconomic Composite (SEC) and a Family Stress Composite. A multivariate general linear model evaluated the impact of study group and sex on the 4 composite scales of the Behavioral Assessment System of Children-2. Demographic factors were treated as covariates and interactions with study group (ESA, placebo, and term) were examined.

resultsThe ESA group had significantly better scores than the placebo group on behavioral symptoms (P = .04) and externalizing scales (P = .04). An interaction was observed between study group and SEC (P = .001). A beneficial effect of ESAs was maximal in the children with lower SEC scores.

conclusionsThe beneficial effects of ESAs on childhood behavior were maximal in children with lower SEC scores. ESAs seemed to ameliorate the adverse impact of lower SEC on behavioral domains seen in the placebo group. This effect was independent of the beneficial effect of ESAs on global cognition we reported previously.

trial registrationClinicalTrials.gov: NCT01207778 and NCT00334737.

Indexed as

Child BehaviorChild, PreschoolDarbepoetin alfaEmotionsErythropoietinFamily CharacteristicsFemaleHematinicsHumansInfant, NewbornInfant, PrematureMaleSocioeconomic FactorsDarbepoetin alfaErythropoietinHematinicscognitive developmentdarbepoetinerythropoietinneurodevelopmental outcomevery low birth weight

Identifiers

PMID28185625
PMCPMC6352724
OpenAlexW2587199845

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.