ArticleJournal of the American Geriatrics Society2017
Use of Bladder Antimuscarinics in Older Adults with Impaired Cognition.
Article in Journal of the American Geriatrics Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Concurrent Use of Anticholinergic and Antidementia Medicines in Older Adults with Dementia: A Systematic Review of Prevalence, Predictors and Clinical Outcomes.Medical sciences (Basel, Switzerland) · 2026Pooled it
- Brain Over Bladder: A Systematic Review of Dual Cholinesterase Inhibitor and Urinary Anticholinergic Use.Drugs & aging · 2018Pooled it
- Medication misuse and overuse in community-dwelling persons with dementia.Journal of the American Geriatrics Society · 2023Article
- Article
- A research agenda for promoting continence for people living with dementia in the community: Recommendations based on a critical review and expert-by-experience opinion.Journal of clinical nursing · 2022Review
- Assessment of Patient-Preferred Language to Achieve Goal-Aligned Deprescribing in Older Adults.JAMA network open · 2021Article
- Overactive Bladder Prescribing Considerations: The Role of Polypharmacy, Anticholinergic Burden, and CYP2D6 Drug‒Drug Interactions.Clinical drug investigation · 2021Review
- The Aged Lower Urinary Tract: Deficits in Neural Control Mechanisms.Frontiers in aging · 2021Review
- Commentary on "Cognitive Function and Urologic Medications for Lower Urinary Tract Symptoms".International neurourology journal · 2020Article
- Temporal Trends in the Use of Anticholinergic Drugs Among Older People Living in Long-Term Care Facilities in Helsinki.Drugs & aging · 2020Article
- Efficacy of posterior tibial nerve stimulation (PTNS) on overactive bladder in older adults.European geriatric medicine · 2018Article
- Making a Bad Diagnosis Worse? Suspect Drug Management of Urinary Incontinence in Persons with Dementia.Journal of the American Geriatrics Society · 2017Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo examine the use of antimuscarinics for treating urinary incontinence (UI) in older adults with varying levels of cognition.
designCross-sectional.
settingNational Alzheimer's Coordinating Center from 2005 through 2015.
participantsCommunity-dwelling men and women aged 65 and older (N = 24,106). MEASUREMENTS: Clinicians and staff evaluated each participant's dementia status during annual in-person assessments. Participants or their informants reported all medications taken in the 2 weeks before each study visit.
resultsOverall, 5.2% (95% confidence interval (CI) = 4.9-5.5%) of the cohort took a bladder antimuscarinic. Participants with impaired cognition were more likely to be taking an antimuscarinic than those with normal cognition. Rates of bladder antimuscarinic use were 4.0% (95% CI = 3.6-4.4%) for participants with normal cognition, 5.6% (95% CI = 4.9-6.3%) for those with mild cognitive impairment, and 6.0% (95% CI = 5.5-6.4%) for those with dementia (p < .001). Of 624 participants with dementia who took antimuscarinics, 16% (95% CI = 13-19%) were simultaneously taking other medicines with anticholinergic properties.
conclusionUse of bladder antimuscarinics was more common in older adults with impaired cognition than in those with normal cognition. This use is despite guidelines advising clinicians to avoid prescribing antimuscarinics in individuals with dementia because of their vulnerability to anticholinergic-induced adverse cognitive and functional effects. A substantial proportion of cognitively impaired individuals who took antimuscarinics were simultaneously taking other anticholinergic medications. These findings suggest a need to improve the treatment of UI in individuals with impaired cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.