Evidence map›Paper›PMID 28185021›Full record

ArticleAIDS and behavior2018

Patient-Initiated Repackaging of Antiretroviral Therapy, Viral Suppression and Drug Resistance.

Habib O Ramadhani, Charles Muiruri, Venance P Maro, Balthazar Nyombi, Michael Omondi, Julian B Mushi, Eileen S Lirhunde, John A Bartlett

Abstract read
In one paragraph

Article in AIDS and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Habib O RamadhaniKilimanjaro Christian Medical Centre, (KCMC), Kilimanjaro, P.O Box 3010, Moshi, Tanzania. habibrama@gmail.com.
Charles MuiruriDuke Global Health Institute, Durham, NC, USA.
Venance P MaroKilimanjaro Christian Medical Centre, (KCMC), Kilimanjaro, P.O Box 3010, Moshi, Tanzania.
Balthazar NyombiKilimanjaro Christian Medical Centre, (KCMC), Kilimanjaro, P.O Box 3010, Moshi, Tanzania.
Michael OmondiDuke Global Health Institute, Durham, NC, USA.
Julian B MushiKilema Designated District Hospital, Moshi, Tanzania.
Eileen S LirhundeKibosho Designated District Hospital, Moshi, Tanzania.
John A BartlettDuke Global Health Institute, Durham, NC, USA.
Kilimanjaro Christian Medical Centre · TZDuke Institute for Health Innovation · USDuke Medical Center · US

Funding

Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5M
Sociobehavioral Sciences Research to Improve Care for HIV Infection in TanzaniaD43TW009595 · FIC · KILIMANJARO CHRISTIAN MEDICAL CENTRE · PI Blandina Theophil Mmbaga · 2013 to 2026
$4.2M
AIDS International Training and Research ProgramD43TW006732 · FIC · DUKE UNIVERSITY · PI BARTLETT, JOHN A · 2004 to 2012
$2.7M
FIC NIH HHS D43 TW006732FIC NIH HHS D43 TW009595NIAID NIH HHS P30 AI064518
6 · The paper itself

Abstract

Patient-initiated repackaging of antiretroviral therapy (ART) refers to removal of ART medications from their original manufacturer's containers, and putting them into alternative containers. This behavior may be triggered by stigma associated with HIV infection, and may impact patient outcomes. We assessed association between patient initiated repackaging of ART and failure to achieve viral suppression (FVS) in a sample of 450 HIV-infected adults (≥8 years) on first line ART for ≥6 months. FVS was defined as a plasma HIV RNA level ≥400 copies/mL. A total of 197 (43.7%) patients reported repackaging their ART medications. One hundred ninety-one patients (42.4%) failed to suppress and FVS was associated with medication repackaging [adjusted odds ratio (aOR), 2.2; 95% CI 1.4-3.3.] Adherence to ART was also associated with FVS (aOR; 0.4; 95% CI 0.2-0.6.). Benefits of retaining drugs in their original packaging along with adherence to ART should be emphasized to reduce the risk of FVS.

Indexed as

Antiretroviral Therapy, Highly ActiveDrug MonitoringSocial StigmaAdultAnti-HIV AgentsCD4 Lymphocyte CountCross-Sectional StudiesDrug PackagingDrug ResistanceFemaleHIV InfectionsHumansMaleMiddle AgedOdds RatioPrevalenceAnti-HIV AgentsART resistance mutationsHIVRepackaging of anti-retro-viralStigmaVirological suppression

Identifiers

PMID28185021
PMCPMC5550377
OpenAlexW2586304098

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.