Evidence map›Paper›PMID 28184416›Full record

ReviewAnnals of oncology : official journal of the European Society for Medical Oncology2017

Best practices for the management of local-regional recurrent chordoma: a position paper by the Chordoma Global Consensus Group.

S Stacchiotti, A Gronchi, P Fossati, T Akiyama, C Alapetite, M Baumann, J Y Blay, S Bolle, S Boriani, P Bruzzi and 55 more

Open access · bronzeAbstract readReviewConsensus Statement
In one paragraph

Review in Annals of oncology : official journal of the European Society for Medical Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed
15.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 236 citations in OpenAlex.

  1. Development and validation of MRI-based radiomics models for predicting recurrence in patients with spine and pelvis chordomas.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  2. Review
  3. Recurrent clival chordoma with spinal and pulmonary metastasis: a case report.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Late recurrence of cervical spine chordoma: illustrative case.Journal of neurosurgery. Case lessons · 2025
    Article
  13. Article
  14. Review
  15. Article
  16. Thoracic spine metastases from lung cancer with incomplete paralysis treated by endoscopic spinal surgery: a case report.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
    Article
  17. Article
  18. Article
  19. Review
  20. Endoscopic Endonasal Resection of Clival Chordomas.Advances and technical standards in neurosurgery · 2025
    Review

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

65 authors at 20 institutions in 14 countries.

S StacchiottiDepartments of Cancer Medicine.
A GronchiSurgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan.
P FossatiCNAO National Center for Oncological Hadrontherapy, Pavia.
T AkiyamaDepartment of Orthopaedic Surgery, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
C AlapetiteDepartment of Radiotherapy, Institut Curie, Paris.
M BaumannDepartment of Radiation Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
J Y BlayCancer Medicine Department, Centre Léon Bérard, Lyon.
S BolleDepartment of Radiotherapy, Gustave Roussy, Villejuif Cedex, France.
S BorianiDepartment of Degenerative and Oncological Spine Surgery, Rizzoli Institute Bologna, Bologna.
P BruzziDepartment of Epidemiology, IRCCS Azienda Ospedaliera Universitaria San Martino, IST Istituto Nazionale per la Ricerca sul Cancro, Genova.
R CapannaUniversity Clinic of Orthopedics and Traumatology AO Pisa, Pisa.
A CaraceniPalliative Care Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan.
R CasadeiOrthopedic Department, Rizzoli Institute Bologna, Bologna, Italy.
V ColiaDepartments of Cancer Medicine.
J DebusDepartment of Radiation Oncology, University of Heidelberg, Heidelberg, Germany.
T DelaneyDepartment of Radiation Oncology, Francis H. Burr Proton Therapy Center, Massachusetts General Hospital, Boston, USA.
A DesaiMidlands Abdominal and Retroperitoneal Sarcoma Unit (MARSU), Queen Elizabeth Hospital, Birmingham.
P DileoDepartment of Oncology, University College London Hospitals (UCLH), London, UK.
S DijkstraDepartment of Orthopaedic Surgery, Leiden University Medical Centre, Leiden, The Netherlands.
F DogliettoInstitute of Neurosurgery, University of Brescia, Brescia, Italy.
A FlanaganUniversity College London Cancer Institute, London.
S FroelichDepartment of Neurosurgery, Paris Diderot University, Hôpital Lariboisière, Paris, France.
P A GardnerDepartment of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, USA.
H GelderblomDepartment of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands.
Z L GokaslanDepartment of Neurosurgery, Brown University School of Medicine, Providence, USA.
R HaasDepartment of Radiotherapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
C HeeryLaboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, Bethesda, USA.
N HindiDepartment of Cancer Medicine, Hospital Universitario Virgen del Rocio, Sevilla, Spain.
P HohenbergerSarcoma Unit, Interdisciplinary Tumor Center, Mannheim University Medical Center, University of Heidelberg, Mannheim, Germany.
F HornicekDepartment of Orthopedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
R ImaiNational Institute of Radiological Sciences, Research Center Hospital for Charged Particle Therapy, Chiba, Japan.
L JeysDepartment of Orthopaedics, Royal Orthopaedic Hospital Birmingham, Birmingham.
R L JonesSarcoma Unit, Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, UK.
B KasperSarcoma Unit, Interdisciplinary Tumor Center, Mannheim University Medical Center, University of Heidelberg, Mannheim, Germany.
A KawaiMusculoskeletal Oncology and Rehabilitation Medicine, National Cancer Center, Tokio, Japan.
M KrengliRadiotherapy Department, University of Piemonte Orientale, Novara, Italy.
A LeithnerDepartment of Orthopaedics and Orthopaedic Surgery, Medical University Graz, Graz, Austria.
I LogowskaDepartment of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
J Martin BrotoDepartment of Cancer Medicine, Hospital Universitario Virgen del Rocio, Sevilla, Spain.
D MazzatentaDepartment of Neurosurgery, IRCCS Istituto delle Scienze Neurologiche, Bologna.
C MorosiDepartment of Radiology, Fondazione IRCCS Istituto Nazionale Tumori, Milan.
P NicolaiDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Brescia, Brescia, Italy.
O J NorumDepartment of Tumor Orthopedic Surgery, The Norwegian Radium Hospital, Oslo, Norway.
S PatelDepartment of Sarcoma Medical Oncology, MD Anderson Cancer Center, Houston, USA.
N PenelCencer Medicine Department, Oscar Lambret Cancer Centre, Lille, France.
P PicciLaboratory of Oncologic Research, Istituto Ortopedico Rizzoli, Bologna.
S PilottiLaboratory of Molecular Pathology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
S RadaelliSurgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan.
F RicchiniPalliative Care Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan.
P RutkowskiDepartment of Soft Tissue/Bone Sarcoma and Melanoma, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
S ScheiplDepartment of Orthopaedics and Orthopaedic Surgery, Medical University Graz, Graz, Austria.
C SenDepartment of Neurosurgery, NYU Langone Medical Center, New York.
E TamboriniLaboratory of Molecular Pathology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
K A ThorntonCenter for Bone and Soft Tissue Sarcoma, Brigham and Women's Hospital/Dana-Farber Cancer Institute, Harvard Medical School, Boston, USA.
B TimmermannParticle Therapy Department, West German Proton Therapy Centre Essen, University Hospital Essen, Essen, Germany.
V TorriOncology Unit, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
P U TunnDepartment of Orthopaedic Oncology, HELIOS Klinikum Berlin-Buch, Berlin, Germany.
M UhlDepartment of Radiation Oncology, University of Heidelberg, Heidelberg, Germany.
Y YamadaDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, USA.
D C WeberPaul Scherrer Institut PSI, Villigen, Switzerland.
D VanelDepartment of Radiology, Istituto Ortopedico Rizzoli, Bologna, Italy.
P P VargaNational Center for Spinal Disorders, Budapest, Hungary.
C L A Vleggeert-LankampDepartment of Neurosurgery, Leiden University Medical Centre, Leiden, The Netherlands.
P G CasaliDepartments of Cancer Medicine.
J SommerChordoma Foundation, Durham, USA.
Fondazione IRCCS Istituto Nazionale dei Tumori · ITIstituto Ortopedico Rizzoli · ITHeidelberg University · DELeiden University Medical Center · NLHospital Universitario Virgen del Rocío · ESMedical University of Graz · ATThe Maria Sklodowska-Curie National Research Institute of Oncology · PLUniversity of Brescia · ITBrigham and Women's Hospital · USBrown University · USCenter for Cancer Research · USCentre Léon Bérard · FRCentre Oscar Lambret · FRChordoma Foundation · USEssen University Hospital · DEEuropean Institute of Oncology · ITHarvard University · USHelios Hospital Berlin-Buch · DEHôpital Lariboisière · FRInstitut Curie · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chordomas are rare, malignant bone tumors of the skull-base and axial skeleton. Until recently, there was no consensus among experts regarding appropriate clinical management of chordoma, resulting in inconsistent care and suboptimal outcomes for many patients. To address this shortcoming, the European Society of Medical Oncology (ESMO) and the Chordoma Foundation, the global chordoma patient advocacy group, convened a multi-disciplinary group of chordoma specialists to define by consensus evidence-based best practices for the optimal approach to chordoma. In January 2015, the first recommendations of this group were published, covering the management of primary and metastatic chordomas. Additional evidence and further discussion were needed to develop recommendations about the management of local-regional failures. Thus, ESMO and CF convened a second consensus group meeting in November 2015 to address the treatment of locally relapsed chordoma. This meeting involved over 60 specialists from Europe, the United States and Japan with expertise in treatment of patients with chordoma. The consensus achieved during that meeting is the subject of the present publication and complements the recommendations of the first position paper.

Indexed as

Practice Guidelines as TopicChordomaHumansNeoplasm Recurrence, Localchemotherapychordomaradiotherapyrelapsesarcomasurgery

Identifiers

PMID28184416
PMCPMC5452071
OpenAlexW2586748258

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.