ReviewFrontiers in chemistry2017
Metaproteomics as a Complementary Approach to Gut Microbiota in Health and Disease.
Review in Frontiers in chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Is there a role of faecal microbiota transplantation in reducing antibiotic resistance burden in gut? A systematic review and Meta-analysis.Annals of medicine · 2021Pooled it
- A Selective History of Protein Sequencing and the Impact of Donald F. Hunt on Protein Sequencing by Tandem Mass Spectrometry.Journal of proteome research · 2026Review
- Cryptosporidium spp. infection drives distinct alterations in the faecal extracellular vesicles metaproteome of calves.Journal of animal science and biotechnology · 2026Article
- Dynamic remodeling of the gut microbiome and host responses after myocardial infarction revealed by longitudinal metaproteomics.Frontiers in microbiology · 2026Article
- The gut microbiome: an emerging epicenter of antimicrobial resistance?Frontiers in microbiology · 2025Review
- Exploring the exoproteome of the parasitic nematodeFrontiers in immunology · 2025Article
- Article
- Contigs directed gene annotation (ConDiGA) for accurate protein sequence database construction in metaproteomics.Microbiome · 2024Article
- Data-independent acquisition boosts quantitative metaproteomics for deep characterization of gut microbiota.NPJ biofilms and microbiomes · 2023Article
- Statistical Evaluation of Metaproteomics and 16S rRNA Amplicon Sequencing Techniques for Study of Gut Microbiota Establishment in Infants with Cystic Fibrosis.Microbiology spectrum · 2022Article
- Towards standardized and reproducible research in skin microbiomes.Environmental microbiology · 2022Review
- Ecosystem-specific microbiota and microbiome databases in the era of big data.Environmental microbiome · 2022Review
- Metaproteomics Approach and Pathway Modulation in Obesity and Diabetes: A Narrative Review.Nutrients · 2021Review
- ITS2 Sequencing and Targeted Meta-Proteomics of Infant Gut Mycobiome Reveal the Functional Role ofJournal of fungi (Basel, Switzerland) · 2021Article
- Techniques Used for Analyzing Microplastics, Antimicrobial Resistance and Microbial Community Composition: A Mini-Review.Frontiers in microbiology · 2021Review
- Gut Microbiota in Adipose Tissue Dysfunction Induced Cardiovascular Disease: Role as a Metabolic Organ.Frontiers in endocrinology · 2021Review
- The Association Between Intestinal Bacteria and Allergic Diseases-Cause or Consequence?Frontiers in cellular and infection microbiology · 2021Review
- Proteomics and Metaproteomics Add Functional, Taxonomic and Biomass Dimensions to Modeling the Ecosystem at the Mucosal-luminal Interface.Molecular & cellular proteomics : MCP · 2020Review
- Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity.Nature communications · 2020Article
- MetaRibo-Seq measures translation in microbiomes.Nature communications · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Classic studies on phylotype profiling are limited to the identification of microbial constituents, where information is lacking about the molecular interaction of these bacterial communities with the host genome and the possible outcomes in host biology. A range of OMICs approaches have provided great progress linking the microbiota to health and disease. However, the investigation of this context through proteomic mass spectrometry-based tools is still being improved. Therefore, metaproteomics or community proteogenomics has emerged as a complementary approach to metagenomic data, as a field in proteomics aiming to perform large-scale characterization of proteins from environmental microbiota, such as the human gut. The advances in molecular separation methods coupled with mass spectrometry (e.g., LC-MS/MS) and proteome bioinformatics have been fundamental in these novel large-scale metaproteomic studies, which have further been performed in a wide range of samples including soil, plant and human environments. Metaproteomic studies will make major progress if a comprehensive database covering the genes and expresses proteins from all gut microbial species is developed. To this end, we here present some of the main limitations of metaproteomic studies in complex microbiota environments, such as the gut, also addressing the up-to-date pipelines in sample preparation prior to fractionation/separation and mass spectrometry analysis. In addition, a novel approach to the limitations of metagenomic databases is also discussed. Finally, prospects are addressed regarding the application of metaproteomic analysis using a unified host-microbiome gene database and other meta-OMICs platforms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.