ArticleClinical interventions in aging2017
Multimorbidity as specific disease combinations, an important predictor factor for mortality in octogenarians: the Octabaix study.
Article in Clinical interventions in aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Digital Predictors of Morbidity, Hospitalization, and Mortality Among Older Adults: A Systematic Review and Meta-Analysis.Frontiers in digital health · 2020Pooled it
- Pulmonary Arterial Hypertension in Octogenarians: The Pulmonary Hypertension Association Registry.Pulmonary circulation · 2026Article
- Association between multimorbidity patterns and activities of daily living function among older adults in China: a longitudinal population-based cohort study.BMC geriatrics · 2025Article
- The impact of diabetes mellitus and chronic obstructive pulmonary disease on mortality among people with dementia: a nationwide population-based cohort study.BMC geriatrics · 2025Article
- Assessing the relationship between multimorbidity, NCD configurations, frailty phenotypes, and mortality risk in older adults.BMC geriatrics · 2024Article
- Adjusted morbidity groups and survival: a retrospective cohort study of primary care patients with chronic conditions.BMC primary care · 2023Observational
- Global and regional prevalence of multimorbidity in the adult population in community settings: a systematic review and meta-analysis.EClinicalMedicine · 2023Article
- Components of case management in caring for patients with dementia: a mixed-methods study.BMC nursing · 2022Article
- Is polypharmacy associated with mortality in the very old: Findings from the Newcastle 85+ Study.British journal of clinical pharmacology · 2022Article
- Pre-existing chronic physical morbidity and excess mortality in people with schizophrenia: a population-based cohort study.Social psychiatry and psychiatric epidemiology · 2022Article
- Associations between multiple long-term conditions and mortality in diverse ethnic groups.PloS one · 2022Article
- Article
- Development and Validation of a Multimorbidity Index Predicting Mortality Among Older Chinese Adults.Frontiers in aging neuroscience · 2022Article
- Aggregation and combination of cardiovascular risk factors and their association with 10-year all-cause mortality: the PERU MIGRANT Study.BMC cardiovascular disorders · 2021Article
- Body mass index, performance on activities of daily living and cognition: analysis in two different populations.BMC geriatrics · 2021Article
- Tracking Multimorbidity Changes in Diverse Racial/Ethnic Populations Over Time: Issues and Considerations.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
- Gender Differences between Multimorbidity and All-Cause Mortality among Older Adults.Current gerontology and geriatrics research · 2020Article
- Validation and Comparison of a Modified Elixhauser Index for Predicting In-Hospital Mortality in Italian Internal Medicine Wards.Risk management and healthcare policy · 2020Article
- Prognostic value of health-related quality of life in elderly patients hospitalized with heart failure.Clinical interventions in aging · 2019Observational
- Prevalence of multimorbidity in subjects aged ≥60 years in a developing country.Clinical interventions in aging · 2018Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe population is aging and multimorbidity is becoming a common problem in the elderly.
objectiveTo explore the effect of multimorbidity patterns on mortality for all causes at 3- and 5-year follow-up periods. MATERIALS AND
methodsA prospective community-based cohort (2009-2014) embedded within a randomized clinical trial was conducted in seven primary health care centers, including 328 subjects aged 85 years at baseline. Sociodemographic variables, sensory status, cardiovascular risk factors, comorbidity, and geriatric tests were analyzed. Multimorbidity patterns were defined as combinations of two or three of 16 specific chronic conditions in the same individual.
resultsOf the total sample, the median and interquartile range value of conditions was 4 (3-5). The individual morbidities significantly associated with death were chronic obstructive pulmonary disease (COPD; hazard ratio [HR]: 2.47; 95% confidence interval [CI]: 1.3; 4.7), atrial fibrillation (AF; HR: 2.41; 95% CI: 1.3; 4.3), and malignancy (HR: 1.9; 95% CI: 1.0; 3.6) at 3-year follow-up; whereas dementia (HR: 2.04; 95% CI: 1.3; 3.2), malignancy (HR: 1.84; 95% CI: 1.2; 2.8), and COPD (HR: 1.77; 95% CI: 1.1; 2.8) were the most associated with mortality at 5-year follow-up, after adjusting using Barthel functional index (BI). The two multimorbidity patterns most associated with death were AF, chronic kidney disease (CKD), and visual impairment (HR: 4.19; 95% CI: 2.2; 8.2) at 3-year follow-up as well as hypertension, CKD, and malignancy (HR: 3.24; 95% CI: 1.8; 5.8) at 5 years, after adjusting using BI.
conclusionMultimorbidity as specific combinations of chronic conditions showed an effect on mortality, which would be higher than the risk attributable to individual morbidities. The most important predicting pattern for mortality was the combination of AF, CKD, and visual impairment after 3 years. These findings suggest that a new approach is required to target multimorbidity in octogenarians.
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