ArticleBritish dental journal2017
Gastrointestinal diseases and their oro-dental manifestations: Part 4: Peutz-Jeghers syndrome.
Article in British dental journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- A survey to evaluate the knowledge of Syrian dental students about oral manifestation of systemic diseases: A cross-sectional study.Medicine · 2026Article
- Peutz-Jeghers Syndrome Presenting With Iron-Deficiency Anaemia and a Giant Colonic Polyp.Cureus · 2025Article
- Cancer Risk of Peutz-Jeghers Syndrome and Treatment Experience: A Chinese Medical Center.Clinics in colon and rectal surgery · 2023Review
- Knowledge and Interdisciplinary Communication of Gastroenterologists and Dentists in the Netherlands About Gastrointestinal Diseases With Oral Manifestations.Crohn's & colitis 360 · 2022Article
- Ultrasonography with the colonic segment-approach for colonic polyps in children.Pediatric radiology · 2019Article
- Hereditary Polyposis Syndromes.Current treatment options in gastroenterology · 2019Review
- Variations of oral anatomy and common oral lesions.Anais brasileiros de dermatologiaArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peutz-Jeghers syndrome (PJS) is a rare, autosomal dominant inherited disorder, caused by germline mutations in the LKB1 tumour suppressor gene. It is clinically characterised by distinct perioral mucocutaneous pigmentations, gastrointestinal polyposis and an increased cancer risk in adult life. Hamartomatous polyps can develop already in the first decade of life and may cause various complications, including abdominal pain, bleeding, anaemia, and acute intestinal obstruction. Furthermore, patients have an increased risk for developing cancer, both in the gastrointestinal tract as in other organs. The medical management of PJS mainly consists of surveillance and treatment of the hamartomatous polyps. Upper and lower endoscopies are recommended for surveillance and removal of PJS polyps in the stomach and the small and large intestine. Furthermore, the high risk for pancreatic cancer justifies surveillance of the pancreatic region by MRI or endoscopic ultrasound. In addition, breast and gynaecological surveillance is recommended for female patients. Although the genetic defect underlying PJS is known, the pathogenesis of hamartomas and carcinomas is unclear. More insight into the molecular background of PJS might lead to targeted therapies for patients with this syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.