Evidence map›Paper›PMID 28184012›Full record

ArticleMolecular cancer research : MCR2017

Chromosome 20q Amplification Defines a Subtype of Microsatellite Stable, Left-Sided Colon Cancers with Wild-type RAS/RAF and Better Overall Survival.

Ryan N Ptashkin, Carlos Pagan, Rona Yaeger, Sumit Middha, Jinru Shia, Kevin P O'Rourke, Michael F Berger, Lu Wang, Robert Cimera, Jiajing Wang and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Mining cancer genomes for copy number alterations identifies glycosylation enzymes as oncogenic drivers.Proceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Ryan N PtashkinDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Carlos PaganDepartment of Pathology, Columbia University Medical Center, New York, New York.
Rona YaegerDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Sumit MiddhaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Jinru ShiaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Kevin P O'RourkeHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Michael F BergerDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Lu WangDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Robert CimeraDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Jiajing WangDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
David S KlimstraDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Leonard SaltzDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Marc LadanyiDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Ahmet ZehirDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.
Jaclyn F HechtmanDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York. hechtmaj@mskcc.org.
Memorial Sloan Kettering Cancer Center · USColumbia University Irving Medical Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Here, comprehensive analysis was performed on the molecular and clinical features of colorectal carcinoma harboring chromosome 20q amplification. Tumor and normal DNA from patients with advanced colorectal carcinoma underwent next-generation sequencing via MSK-IMPACT, and a subset of case samples was subjected to high-resolution microarray (Oncoscan). Relationships between genomic copy number and transcript expression were assessed with The Cancer Genome Atlas (TCGA) colorectal carcinoma data. Of the colorectal carcinoma patients sequenced (

Indexed as

Microsatellite InstabilityAntibodies, MonoclonalCetuximabChromosomes, Human, Pair 20Colonic NeoplasmsColorectal NeoplasmsErbB ReceptorsHumansMutationPanitumumabProportional Hazards Modelsraf Kinasesras ProteinsSurvival AnalysisAntibodies, MonoclonalCetuximabEGFR protein, humanErbB ReceptorsPanitumumabraf Kinasesras Proteins

Identifiers

PMID28184012
PMCPMC5588907
OpenAlexW2587193798

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.