ArticleJournal of applied physiology (Bethesda, Md. : 1985)2017
A chronic physical activity treatment in obese rats normalizes the contributions of ET-1 and NO to insulin-mediated posterior cerebral artery vasodilation.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Effect of Phenylephrine on Cerebrovascular Regulation: A Translational Perspective.Journal of the American Heart Association · 2025Article
- Sex-dependent effects of a high-fat diet-induced obesity model on cerebrovascular health and brain metabolism.Experimental physiology · 2025Article
- Effect of insulin on indices of cerebral blood flow and cerebrovascular compliance in young adults.American journal of physiology. Heart and circulatory physiology · 2025Article
- Effects of dietary soy content on cerebral artery function and behavior in ovariectomized female mice.American journal of physiology. Heart and circulatory physiology · 2024Article
- The Fidget Factor and the obesity paradox. How small movements have big impact.Frontiers in sports and active living · 2023Article
- Exercise protects vascular function by countering senescent cells in older adults.Frontiers in physiology · 2023Review
- The role of nitric oxide in flow-induced and myogenic responses in 1A, 2A, and 3A branches of the porcine middle cerebral artery.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- ADAM17 cleaves the insulin receptor ectodomain on endothelial cells and causes vascular insulin resistance.American journal of physiology. Heart and circulatory physiology · 2022Article
- Obesity-induced cognitive impairment in older adults: a microvascular perspective.American journal of physiology. Heart and circulatory physiology · 2021Article
- Metformin May Contribute to Inter-individual Variability for Glycemic Responses to Exercise.Frontiers in endocrinology · 2020Review
- Obesity-related cognitive impairment: The role of endothelial dysfunction.Neurobiology of disease · 2019Review
- Persistent insulin signaling coupled with restricted PI3K activation causes insulin-induced vasoconstriction.American journal of physiology. Heart and circulatory physiology · 2019Article
- Exercise and Vascular Insulin Sensitivity in the Skeletal Muscle and Brain.Exercise and sport sciences reviews · 2019Review
- Female Sex Hormones and Cardiac Pressure Overload Independently Contribute to the Cardiogenic Dementia Profile in Yucatan Miniature Swine.Frontiers in cardiovascular medicine · 2019Article
- Microvascular insulin resistance in skeletal muscle and brain occurs early in the development of juvenile obesity in pigs.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Cardiovascular Effects and Benefits of Exercise.Frontiers in cardiovascular medicine · 2018Review
- Insulin-Stimulated Bone Blood Flow and Bone Biomechanical Properties Are Compromised in Obese, Type 2 Diabetic OLETF Rats.JBMR plus · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
This study tested the hypotheses that obesity-induced decrements in insulin-stimulated cerebrovascular vasodilation would be normalized with acute endothelin-1a receptor antagonism and that treatment with a physical activity intervention restores vasoreactivity to insulin through augmented nitric oxide synthase (NOS)-dependent dilation. Otsuka Long-Evans Tokushima Fatty rats were divided into the following groups: 20 wk old food controlled (CON-20); 20 wk old free food access (model of obesity, OB-20); 40 wk old food controlled (CON-40); 40 wk old free food access (OB-40); and 40 wk old free food access+RUN (RUN-40; wheel-running access from 20 to 40 wk). Rats underwent Barnes maze testing and a euglycemic hyperinsulinemic clamp (EHC). In the 40-wk cohort, cerebellum and hippocampus blood flow (BF) were examined (microsphere infusion). Vasomotor responses (pressurized myography) to insulin were assessed in untreated, endothelin-1a receptor antagonism, and NOS inhibition conditions in posterior cerebral arteries. Insulin-stimulated vasodilation was attenuated in the OB vs. CON and RUN groups (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.