Evidence map›Paper›PMID 28183815›Full record

ArticleMolecular & cellular proteomics : MCP2017

Proteomic Screen for Cellular Targets of the Vaccinia Virus F10 Protein Kinase Reveals that Phosphorylation of mDia Regulates Stress Fiber Formation.

Matthew D Greseth, Dominique C Carter, Scott S Terhune, Paula Traktman

Open access · hybridAbstract read
In one paragraph

Article in Molecular & cellular proteomics : MCP, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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  9. The Host-Pathogen Ecosystem Viewed Through the Prism of Proteomics.Molecular & cellular proteomics : MCP · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Matthew D GresethFrom the ‡Departments of Biochemistry & Molecular Biology and Microbiology & Immunology, and Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.
Dominique C Carter§Department of Microbiology & Molecular Genetics and the Biotechnology & Bioengineering Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
Scott S Terhune§Department of Microbiology & Molecular Genetics and the Biotechnology & Bioengineering Center, Medical College of Wisconsin, Milwaukee, Wisconsin.
Paula TraktmanFrom the ‡Departments of Biochemistry & Molecular Biology and Microbiology & Immunology, and Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina; traktman@musc.edu.ORCID 0000-0002-6517-0225
Medical College of Wisconsin · USMUSC Hollings Cancer Center · US

Funding

Impact of HCMV proteins on viral replication and cellular signaling pathwaysR01AI083281 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI TERHUNE, SCOTT SLETTEN · 2011 to 2020
$3.2M
Biogenesis of the Poxvirus MembraneR01AI107123 · NIAID · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TRAKTMAN, PAULA · 2015 to 2019
$1.9M
Vaccinia Encoded Kinases and PhosphatasesR01AI063620 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI TRAKTMAN, PAULA · 2005 to 2009
$1.8M
NIAID NIH HHS R01 AI063620NIAID NIH HHS R01 AI083281NIAID NIH HHS R01 AI107123
6 · The paper itself

Abstract

Vaccinia virus, a complex dsDNA virus, is unusual in replicating exclusively within the cytoplasm of infected cells. Although this prototypic poxvirus encodes >200 proteins utilized during infection, a significant role for host proteins and cellular architecture is increasingly evident. The viral B1 kinase and H1 phosphatase are known to target cellular proteins as well as viral substrates, but little is known about the cellular substrates of the F10 kinase. F10 is essential for virion morphogenesis, beginning with the poorly understood process of diversion of membranes from the ER for the purpose of virion membrane biogenesis. To better understand the function of F10, we generated a cell line that carries a single, inducible F10 transgene. Using uninduced and induced cells, we performed

Indexed as

Adaptor Proteins, Signal TransducingGene Expression Regulation, ViralHumansIsotope LabelingPhosphoproteinsPhosphorylationProtein Interaction MapsProtein Serine-Threonine KinasesProteomicsSerineStress FibersVaccinia virusViral ProteinsAdaptor Proteins, Signal TransducingPhosphoproteinsprotein kinase 2, Vaccinia virusProtein Serine-Threonine KinasesSerineViral Proteins

Identifiers

PMID28183815
PMCPMC5393388
OpenAlexW2587314759

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.