Observational studyBMJ open2017
Observational study of haemostatic dysfunction and bleeding in neonates with hypoxic-ischaemic encephalopathy.
Observational study in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Platelet transfusion thresholds for thrombocytopenic infants.The Cochrane database of systematic reviews · 2026Pooled it
- Transfusion Burden in Neonates with Hypoxic-Ischemic Encephalopathy Undergoing Therapeutic Hypothermia.Children (Basel, Switzerland) · 2026Article
- Hemostatic Status of Neonates with Perinatal Hypoxia, Studied via NATEM in Cord Blood Samples.Children (Basel, Switzerland) · 2024Article
- Prognostic analysis of elderly patients with pathogenic microorganisms positive for sepsis-associated encephalopathy.Frontiers in microbiology · 2024Article
- TEGDiagnostics (Basel, Switzerland) · 2021Review
- Variation in Neonatal Transfusion Practice.The Journal of pediatrics · 2021Article
- Risk factors and treatments for disseminated intravascular coagulation in neonates.Italian journal of pediatrics · 2020Article
- Management of Multi Organ Dysfunction in Neonatal Encephalopathy.Frontiers in pediatrics · 2020Review
- Neonatal and pediatric platelet transfusions: current concepts and controversies.Current opinion in hematology · 2019Review
- Coagulation Profiles Are Associated With Early Clinical Outcomes in Neonatal Encephalopathy.Frontiers in pediatrics · 2019Article
- Hypothermia for encephalopathy in low-income and middle-income countries: feasibility of whole-body cooling using a low-cost servo-controlled device.BMJ paediatrics open · 2018Article
- Recent advances in transfusions in neonates/infants.F1000Research · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveEvaluate the relationship between initial haemostatic parameters and the frequency and severity of bleeding in neonates with hypoxic-ischaemic encephalopathy (HIE).
designRetrospective observational cohort study.
setting2 academically affiliated level III neonatal intensive care units in Atlanta, Georgia.
participants98 neonates with moderate-to-severe HIE who underwent haemostatic testing within 12 hours of birth and were born from 1 January 2008 to 31 December 2013. PRIMARY AND SECONDARY OUTCOME MEASURES: Initial haemostatic dysfunction was defined as one or more of the following: prothrombin time (PT) ≥18 s, platelet count <100×10
resultsAmong the 98 neonates evaluated, the prevalence of initial haemostatic dysfunction was 69% (95% CI 59% to 78%). 27 neonates (28%; 95% CI 19% to 38%) had abnormal bleeding events and 56 (57%) received at least 1 blood product transfusion. 3 neonates died from bleeding complications. The most common products transfused were fresh-frozen plasma (71%), followed by packed red blood cells (24%) and platelets (21%). In multivariable analysis, fibrinogen <150 mg/dL (adjusted relative risk 2.41, 95% CI 1.09 to 5.36) and platelet count <100×10
conclusionsAmong neonates with moderate-to-severe HIE, haemostatic dysfunction is prevalent and associated with an increased risk of bleeding and high transfusion burden. Further studies are needed to determine the appropriate transfusion approaches in this population to prevent bleeding.
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Registered trials
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