Evidence map›Paper›PMID 28183734›Full record

ArticleThe Journal of experimental medicine2017

Skap2 is required for β

Mark Boras, Stephanie Volmering, Arne Bokemeyer, Jan Rossaint, Helena Block, Bernadette Bardel, Veerle Van Marck, Barbara Heitplatz, Stefanie Kliche, Annegret Reinhold and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 63 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Gain-of-function mutation inbioRxiv : the preprint server for biology · 2026
    Article
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  8. Therapeutic Repair of Sperm Quality Decline Caused by Polytetrafluoroethylene.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  9. Article
  10. Review
  11. INTEGRIN FUNCTION IN LEUKOCYTE-MEDIATED INFLAMMATION-ACTINOPATHIES IN IMMUNE DISEASES.Transactions of the American Clinical and Climatological Association · 2025
    Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. βCells · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Mark BorasDepartment of Anesthesiology, Intensive Care, and Pain Medicine, University of Münster, 48149 Münster, Germany.ORCID 0000-0003-0244-7722
Stephanie VolmeringDepartment of Anesthesiology, Intensive Care, and Pain Medicine, University of Münster, 48149 Münster, Germany.
Arne BokemeyerDepartment of Anesthesiology, Intensive Care, and Pain Medicine, University of Münster, 48149 Münster, Germany.ORCID 0000-0002-4238-751X
Jan RossaintDepartment of Anesthesiology, Intensive Care, and Pain Medicine, University of Münster, 48149 Münster, Germany.
Helena BlockDepartment of Anesthesiology, Intensive Care, and Pain Medicine, University of Münster, 48149 Münster, Germany.
Bernadette BardelDepartment of Anesthesiology, Intensive Care, and Pain Medicine, University of Münster, 48149 Münster, Germany.
Veerle Van MarckGerhard-Domagk-Institute of Pathology, University Hospital Münster, University of Münster, 48149 Münster, Germany.
Barbara HeitplatzGerhard-Domagk-Institute of Pathology, University Hospital Münster, University of Münster, 48149 Münster, Germany.
Stefanie KlicheInstitute of Molecular and Clinical Immunology, Otto-von-Guericke University Magdeburg, 39106 Magdeburg, Germany.
Annegret ReinholdInstitute of Molecular and Clinical Immunology, Otto-von-Guericke University Magdeburg, 39106 Magdeburg, Germany.
Clifford LowellDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143.
Alexander ZarbockDepartment of Anesthesiology, Intensive Care, and Pain Medicine, University of Münster, 48149 Münster, Germany zarbock@uni-muenster.de.ORCID 0000-0002-2124-1714
University of Münster · DEOtto-von-Guericke-Universität Magdeburg · DEUniversity of California, San Francisco · US

Funding

Signaling by Cytoplasmic Tyrosine Kinases in LeukocytesR01AI068150 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOWELL, CLIFFORD A · 2006 to 2016
$3.4M
Regulation of Innate Immune Signaling by Lyn KinaseR01AI113272 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOWELL, CLIFFORD A · 2015 to 2019
$2.0M
NIAID NIH HHS R01 AI068150NIAID NIH HHS R01 AI113272
6 · The paper itself

Abstract

Integrin activation is required for neutrophil functions. Impaired integrin activation on neutrophils is the hallmark of leukocyte adhesion deficiency (LAD) syndrome in humans, characterized by impaired leukocyte recruitment and recurrent infections. The Src kinase-associated phosphoprotein 2 (Skap2) is involved in integrin functions in different leukocyte subtypes. However, the role of Skap2 in β

Indexed as

Neutrophil InfiltrationAnimalsCD18 AntigensCell AdhesionChemotaxis, LeukocyteCytoskeletal ProteinsE-SelectinIntracellular Signaling Peptides and ProteinsMacrophage-1 AntigenMiceMice, Inbred C57BLNeutrophilsProtein Multimerizationsrc Homology DomainsTalinWiskott-Aldrich Syndrome ProteinCD18 AntigensCytoskeletal ProteinsE-SelectinIntracellular Signaling Peptides and Proteinskindlin-3 protein, mouseMacrophage-1 Antigensrc kinase associated phosphoprotein 2TalinTln1 protein, mouseWas protein, mouseWiskott-Aldrich Syndrome Protein

Identifiers

PMID28183734
PMCPMC5339670
OpenAlexW2586847280

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.