ArticleParasites & vectors2017
Assessing the impact of intervention strategies against Taenia solium cysticercosis using the EPICYST transmission model.
Article in Parasites & vectors, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Pooled it
- A qualitative assessment of the context and enabling environment for the control of Taenia solium infections in endemic settings.PLoS neglected tropical diseases · 2021Pooled it
- Strategies for tackling Taenia solium taeniosis/cysticercosis: A systematic review and comparison of transmission models, including an assessment of the wider Taeniidae family transmission models.PLoS neglected tropical diseases · 2019Pooled it
- Effectiveness of a community-based educational programme in reducing the cumulative incidence and prevalence of human Taenia solium cysticercosis in Burkina Faso in 2011-14 (EFECAB): a cluster-randomised controlled trial.The Lancet. Global health · 2018Trial
- Mathematical modelling of the effects of public health educational campaigns on the transmission dynamics ofParasite epidemiology and control · 2026Article
- Validation of reference genes for RT-qPCR relative expression analysis during cyst-to-early adult development of Taenia solium.PLoS neglected tropical diseases · 2026Article
- Immunity against reinfection in pigs following Taenia solium infection and a quantitative dose-response model.Research square · 2025Article
- Could a ring treatment approach be proposed to control Taenia solium transmission in a post elimination setting? A pilot study in Zambia.PLoS neglected tropical diseases · 2024Article
- Antibody Banding Patterns on the Enzyme-Linked Immunoelectrotransfer Blot (EITB) Assay Clearly Discriminate Viable Cysticercosis in Naturally Infected Pigs.Pathogens (Basel, Switzerland) · 2023Article
- Insights into the diagnosis, vaccines, and control of Taenia solium, a zoonotic, neglected parasite.Parasites & vectors · 2023Review
- Quantitative risk assessment for humanVeterinary world · 2023Article
- CystiHuman: A model of human neurocysticercosis.PLoS computational biology · 2022Article
- Optimal control analysis ofParasite epidemiology and control · 2022Article
- Validation of a spatial agent-based model for Taenia solium transmission ("CystiAgent") against a large prospective trial of control strategies in northern Peru.PLoS neglected tropical diseases · 2021Article
- Data-driven analyses of behavioral strategies to eliminate cysticercosis in sub-Saharan Africa.PLoS neglected tropical diseases · 2021Article
- Neurocysticercosis: Current Perspectives on Diagnosis and Management.Frontiers in veterinary science · 2021Review
- Force-of-infection of Taenia solium porcine cysticercosis: a modelling analysis to assess global incidence and prevalence trends.Scientific reports · 2020Article
- TSOL18 vaccine and oxfendazole for control of Taenia solium cysticercosis in pigs: A field trial in endemic areas of Tanzania.PLoS neglected tropical diseases · 2020Article
- Understanding transmission and control of the pork tapeworm with CystiAgent: a spatially explicit agent-based model.Parasites & vectors · 2020Article
- Modelling forBulletin of the World Health Organization · 2020Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundThe pork tapeworm, Taenia solium, and associated human infections, taeniasis, cysticercosis and neurocysticercosis, are serious public health problems, especially in developing countries. The World Health Organization (WHO) has set goals for having a validated strategy for control and elimination of T. solium taeniasis/cysticercosis by 2015 and interventions scaled-up in selected countries by 2020. Timely achievement of these internationally-endorsed targets requires that the relative benefits and effectiveness of potential interventions be explored rigorously within a quantitative framework.
methodsA deterministic, compartmental transmission model (EPICYST) was developed to capture the dynamics of the taeniasis/cysticercosis disease system in the human and pig hosts. Cysticercosis prevalence in humans, an outcome of high epidemiological and clinical importance, was explicitly modelled. A next generation matrix approach was used to derive an expression for the basic reproduction number, R
resultsEPICYST outputs indicate that chemotherapeutic intervention targeted at humans or pigs would be highly effective at reducing taeniasis and cysticercosis prevalence when applied singly, with annual chemotherapy of humans and pigs resulting, respectively, in 94 and 74% of human cysticercosis cases averted. Improved sanitation, meat inspection and animal husbandry are less effective but are still able to reduce prevalence singly or in combination. The value of R
conclusionsHuman- and pig-targeted drug-focussed interventions appear to be the most efficacious approach from the options currently available. The model presented is a forward step towards developing an informed control and elimination strategy for cysticercosis. Together with its validation against field data, EPICYST will be a valuable tool to help reach the WHO goals and to conduct economic evaluations of interventions in varying epidemiological settings.
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