Evidence map›Paper›PMID 28183335›Full record

Trial reportTrials2017

Efficacy of vitamin D

Christopher R Sudfeld, Ferdinand Mugusi, Said Aboud, Tumaini J Nagu, Molin Wang, Wafaie W Fawzi

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Trials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01798680 (Trial of Vitamin D in HIV Progression), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01798680 phase3completednot on this map

Trial of Vitamin D in HIV Progression

TypeinterventionalSponsorHarvard School of Public Health (HSPH)Ran2014 to 2019Enrolled4,000ConditionsHIV InfectionArmsVitamin D3 (cholecalciferol), Placebo
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Efficacy of vitamin DThe lancet. HIV · 2020
    Trial
  7. High-Dose Vitamin DAmerican journal of respiratory and critical care medicine · 2017
    Trial
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Changes in tuberculosis in human immunodeficiency virus infected patients in a Spanish tertiary hospital (1995-2013).Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2018
    Observational
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Christopher R SudfeldDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Building I Room 1104C, Boston, MA, 02115, USA. csudfeld@hsph.harvard.edu.
Ferdinand MugusiManagement and Development for Health, Dar es Salaam, Tanzania.
Said AboudManagement and Development for Health, Dar es Salaam, Tanzania.
Tumaini J NaguManagement and Development for Health, Dar es Salaam, Tanzania.
Molin WangDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Wafaie W FawziDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, 665 Huntington Ave, Building I Room 1104C, Boston, MA, 02115, USA.
Harvard Global Health Institute · USMuhimbili University of Health and Allied Sciences · TZHarvard University · USManagement and Development for Health · TZ

Funding

Trial of Vitamin D in HIV ProgressionR01DK098075 · NIDDK · HARVARD SCHOOL OF PUBLIC HEALTH · PI FAWZI, WAFAIE W · 2013 to 2017
$2.6M
NIDDK NIH HHS R01 DK098075
6 · The paper itself

Abstract

backgroundHIV-infected adults initiating antiretroviral therapy (ART) in sub-Saharan Africa continue to experience high rates of morbidity and mortality during the initial months of treatment. Observational studies in high-income and resource-limited settings indicate that HIV-infected adults with low vitamin D levels may be at increased risk of mortality, HIV disease progression, and incidence of pulmonary tuberculosis (TB). As a result, vitamin D METHODS/

designThe Trial of Vitamins-4 (ToV4) is an individually randomized, double-blind, placebo-controlled trial of vitamin D DISCUSSION: The ToV4 will provide causal evidence on the effect of vitamin D

trial registrationClinicalTrials.gov, NCT01798680 . Registered on 21 February 2013.

Indexed as

CoinfectionDietary SupplementsAdministration, OralAIDS-Related Opportunistic InfectionsAnti-Retroviral AgentsCholecalciferolClinical ProtocolsDouble-Blind MethodDrug Administration ScheduleHIV InfectionsHumansImmunocompromised HostIncidenceNutritional StatusProtective FactorsResearch DesignAnti-Retroviral AgentsCholecalciferolCholecalciferolHIVMicronutrientNutritionTanzaniaTuberculosisVitamin D

Identifiers

PMID28183335
PMCPMC5301352
OpenAlexW2586857612

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.