ArticleBMC complementary and alternative medicine2017
Evaluation of the antidiarrheal activity of the leaf extracts of Myrtus communis Linn (Myrtaceae) in mice model.
Article in BMC complementary and alternative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Integrated In Vivo, In Vitro, and In Silico Evaluation of Spermacoce ocymoides Methanolic Extract for Antidiarrheal, Thrombolytic, and Antiarthritic Activities.Cell biochemistry and biophysics · 2026Article
- Unveiling the Therapeutic Spectrum of Annona reticulata Linn.: Antibacterial, Insecticidal, and Antidiarrheal Insights.TheScientificWorldJournal · 2026Article
- Evaluation of the Antidiarrheal Activity of 80% Methanolic Extract and Solvent Fractions of Calpurnia aurea (Ait.) Benth. (Fabaceae) Roots in Swiss Albino Mice.BioMed research international · 2026Article
- Article
- Phytochemical Isolation and Antimicrobial, Thrombolytic, Anti-inflammatory, Analgesic, and Antidiarrheal Activities from the Shell of Commonly AvailableNutrition and metabolic insights · 2025Article
- The therapeutic value of Myrtus communis L.: an updated review.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Article
- Evaluation of hepatoprotective and antidiarrheal activities of the hydromethanol crude extract and solvent fractions ofMetabolism open · 2024Article
- Phyto-pharmacological evaluation and characterization of the methanolic extract of theFrontiers in pharmacology · 2024Article
- Evaluation of the antidiarrheal activity of the 80% hydromethanolic crude extract and solvent fractions ofFrontiers in pharmacology · 2024Article
- Evaluation of In Vivo Antidiarrheal Activities of 80% Methanol Extract and Solvent Fractions of Peels ofEvidence-based complementary and alternative medicine : eCAM · 2024Article
- Antidiarrheal activities of methanolic crude extract and solvent fractions of the root ofHeliyon · 2023Article
- Review of Medicinal Plants Traditionally Used to Treat Diarrhea by the People in the Amhara Region of Ethiopia.Evidence-based complementary and alternative medicine : eCAM · 2023Review
- Antidiarrheal Activities of the Methanol Leaf Extracts ofJournal of experimental pharmacology · 2023Article
- Evaluation of Anti-Diarrheal Activities of the 80% Methanol Extract and Solvent Fractions ofJournal of experimental pharmacology · 2023Article
- Evaluation ofMetabolism open · 2022Article
- Chemical and Pharmacological Profiling ofMolecules (Basel, Switzerland) · 2022Article
- Article
- Evaluation of the antidiarrheal activity of 80% methanol extract and solvent fractions of the leaf of Bersama abyssinica fresen (Melianthaceae) in mice.BMC complementary medicine and therapies · 2022Article
- Evaluation of Antidiarrheal Activity of 80% Methanol Extract and Solvent Fractions of the Leaves ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
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3 authors.
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Abstract
backgroundMyrtus communis L. has a folkloric repute for the management of diarrhea and dysentery in different parts of the world. However, the safety and efficacy of the leaf extract have not been scientifically validated in animal model. This study was, therefore, aimed to investigate the antidiarrheal effect of 80% methanol extract (80ME) and solvent fractions of the leaves of Myrtus communis L. in mice.
methodsThe antidiarrheal activity of the 80ME and solvent fractions was evaluated against castor oil induced diarrheal model, charcoal meal and enteropooling tests. For the 80%ME, the test groups received 100, 200 and 400 mg/kg of the extract. In case of fractions, the test groups received various doses of fractions (200, 300, 400 mg/kg and an additional dose of 800 mg/kg for the aqueous fraction (AF)), where as negative controls received the vehicle (10 ml/kg) and positive controls received loperamide (3 mg/kg).
resultsThe 80ME at 200 mg/kg (p < 0.05) & 400 mg/kg (p < 0.01) as well as the chloroform fraction (CF) and methanol fraction (MF) at 400 mg/kg (p < 0.05) significantly delayed the onset of diarrhea. Besides, the 80ME (at all tested doses) and both of these fractions (at 300 & 400 mg/kg) significantly decreased the frequency and weight of fecal outputs. Results from the charcoal meal test revealed that the 80ME, at all doses, (p < 0.001) as well as the CF and MF at 300 mg/kg (p < 0.05) & 400 mg/kg (p < 0.001) produced a significant anti-motility effect. Similarly, in the entero-pooling test, the 80ME (at all tested doses) (p < 0.01) as well as the CF and MF (at 300 & 400 mg/kg, p < 0.05) produced a significant decline in the weight and volume of intestinal contents, whereas the AF revealed significant effect (p < 0.05) at dose of 800 mg/kg only.
conclusionThe study demonstrated that the 80ME and solvent fractions contain bioactive constituents that have antidiarrheal activity. Therefore, this study provides a scientific support for the acclaimed traditional use of Myrtus communis L for the treatment of diarrheal diseases.
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