ArticleBMC endocrine disorders2017
Genistein treatment improves fracture resistance in obese diabetic mice.
Article in BMC endocrine disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 33 citations in OpenAlex.
- Potential use of the Asteraceae family as a cure for diabetes: A review of ethnopharmacology to modern day drug and nutraceuticals developments.Frontiers in pharmacology · 2023Review
- Genistein: Dual Role in Women's Health.Nutrients · 2021Review
- Genistein and Galantamine Combinations Decrease β-Amyloid PeptideNeurotoxicity research · 2020Article
- Genistein prevents bone loss in type 2 diabetic rats induced by streptozotocin.Food & nutrition research · 2020Article
- Bone Strength Is Improved with Genistein Treatment in Mice with Diet-Induced Obesity.Current developments in nutrition · 2019Article
- Exercise and resveratrol increase fracture resistance in the 3xTg-AD mouse model of Alzheimer's disease.BMC complementary and alternative medicine · 2019Article
- Leptin-deficient mice have altered three-dimensional growth plate histomorphometry.Diabetology & metabolic syndrome · 2019Article
- Intranasal Delivery of Genistein-Loaded Nanoparticles as a Potential Preventive System against Neurodegenerative Disorders.Pharmaceutics · 2018Article
- High-fat, high-sugar diet induces splenomegaly that is ameliorated with exercise and genistein treatment.BMC research notes · 2018Article
- Genistein diet does not modify crypt morphology in the ob/ob mouse jejunum: a comparison of cryostat and clearing techniques.Diabetes, metabolic syndrome and obesity : targets and therapy · 2018Article
- Bone Health and Natural Products- An Insight.Frontiers in pharmacology · 2018Review
- Genistein improves inflammatory response and colonic function through NF-κB signal in DSS-induced colonic injury.Oncotarget · 2017Article
- Genistein protects hippocampal neurons against injury by regulating calcium/calmodulin dependent protein kinase IV protein levels in Alzheimer's disease model rats.Neural regeneration research · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObese, type two diabetics are at an increased risk for fracturing their limb bones in comparison to the general population. Phytoestrogens like as the soy isoflavone genistein have been shown to protect against bone loss. In this study, we tested the effects of genistein treatment on femurs of ob/ob mice, a model for obesity and type two diabetes mellitus.
methodsTwenty six-week-old female mice were divided into obese (ob/ob) control, obese genistein-treated, lean (ob/+) control, and lean genistein-treated groups (n = 5 each). Treatment with genistein consisted of 600 mg genistein/kg diet. Control mice were given standard rodent chow. At the end of a four-week treatment period, bone histomorphometric and three-point bending properties were compared among groups.
resultsObese mice had larger bone areas (B.Ar.; P < 0.05) and total areas (Tt.Ar.; P < 0.05), but similar bone volume (B.Ar./Tt.Ar.; P > 0.05) of the proximal femoral epiphysis in comparison to lean mice. Treatment with genistein decreased Tt.Ar. and femur length, and increased ultimate force required to fracture the femur and the maximum deformation to failure (P < 0.05).
conclusionsGenistein improves resistance to fracture from bending loads.
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