ArticlePharmaceutical biology2017
Antimalarial, antiplasmodial and analgesic activities of root extract of Alchornea laxiflora.
Article in Pharmaceutical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Appraising the therapeutical potentials ofFrontiers in pharmacology · 2022Pooled it
- Antiplasmodial, antimalarial activities and toxicity of African medicinal plants: a systematic review of literature.Malaria journal · 2021Pooled it
- The GenusMolecules (Basel, Switzerland) · 2026Review
- Article
- Article
- In vitro and in vivo antimalarial activity and chemical profiling of sugarcane leaves.Scientific reports · 2022Article
- Natural Antioxidants as Additional Weapons in the Fight against Malarial Parasite.Current topics in medicinal chemistry · 2022Review
- Antimalarial potentials ofJournal of traditional and complementary medicine · 2020Article
- Antimicrobial Importance of Medicinal Plants in Nigeria.TheScientificWorldJournal · 2020Review
- Evaluating Antiplasmodial and Antimalarial Activities of Soybean (Journal of pathogens · 2020Article
- Anti-Plasmodium falciparum Activity of Extracts from 10 Cameroonian Medicinal Plants.Medicines (Basel, Switzerland) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextAlchornea laxiflora (Benth.) Pax. & Hoffman (Euphorbiaceae) root decoctions are traditionally used in the treatment of malaria and pain in Nigeria.
objectiveTo assess the antimalarial, antiplasmodial and analgesic potentials of root extract and fractions against malarial infections and chemically-induced pains. MATERIAL AND
methodsThe root extract and fractions of Alchornea laxiflora were investigated for antimalarial activity against Plasmodium berghei infection in mice, antiplasmodial activity against chloroquine sensitive (Pf 3D7) and resistant (Pf INDO) strains of Plasmodium falciparum using SYBR green assay method and analgesic activity against experimentally-induced pain models. Acute toxicity study of the extract, cytotoxic activity against HeLa cells and GCMS analysis of the active fraction were carried out.
resultsThe root extract (75-225 mg/kg, p.o.) with LD DISCUSSION AND
conclusionsThese results suggest that the root extract/fractions of A. laxiflora possess antimalarial, antiplasmodial and analgesic potentials and these justify its use in ethnomedicine to treat malaria and pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.