ArticleDevelopmental cognitive neuroscience2017
Dyslexia risk gene relates to representation of sound in the auditory brainstem.
Article in Developmental cognitive neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Auditory brainstem response deficits in learning disorders and developmental language disorder: a systematic review and meta-analysis.Scientific reports · 2022Pooled it
- A systematic review and meta-analysis of imaging genetics studies of specific reading disorder.Cognitive neuropsychology · 2021Pooled it
- Linking Auditory Brainstem Neural Stability to Parent-Reported Autistic Traits in School-Age Children.Brain sciences · 2026Article
- Article
- Individual differences in the perception of phonetic category structure predict speech-in-noise performance.The Journal of the Acoustical Society of America · 2024Article
- Elevated unanticipated acoustic startle reactivity in dyslexia.Dyslexia (Chichester, England) · 2024Article
- Auditory Category Learning in Children With Dyslexia.Journal of speech, language, and hearing research : JSLHR · 2024Article
- Cumulative genetic score of KIAA0319 affects reading ability in Chinese children: moderation by parental education and mediation by rapid automatized naming.Behavioral and brain functions : BBF · 2023Article
- Gender Effects on Binaural Speech Auditory Brainstem Response.The journal of international advanced otology · 2022Article
- Animal models of developmental dyslexia.Frontiers in neuroscience · 2022Review
- Theory-driven classification of reading difficulties from fMRI data using Bayesian latent-mixture models.NeuroImage · 2021Article
- Neural processing of vision and language in kindergarten is associated with prereading skills and predicts future literacy.Human brain mapping · 2021Article
- The 100 Top-Cited Studies on Dyslexia Research: A Bibliometric Analysis.Frontiers in psychiatry · 2021Article
- Identification of Phonology-Related Genes and Functional Characterization of Broca's and Wernicke's Regions in Language and Learning Disorders.Frontiers in neuroscience · 2021Article
- From Schools to Scans: A Neuroeducational Approach to Comorbid Math and Reading Disabilities.Frontiers in public health · 2020Article
- Project DyAdd: Non-linguistic Theories of Dyslexia Predict Intelligence.Frontiers in human neuroscience · 2020Article
- Pinyin Is an Effective Proxy for Early Screening for Mandarin-Speaking Children at Risk of Reading Disorders.Frontiers in psychology · 2020Article
- Analyzing the FFR: A tutorial for decoding the richness of auditory function.Hearing research · 2019Review
- Disrupted left fusiform response to print in beginning kindergartners is associated with subsequent reading.NeuroImage. Clinical · 2019Article
- Increased variability of stimulus-driven cortical responses is associated with genetic variability in children with and without dyslexia.Developmental cognitive neuroscience · 2018Article
Corrections and comments
- Erratum issuedErratum.2020
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dyslexia is a reading disorder with strong associations with KIAA0319 and DCDC2. Both genes play a functional role in spike time precision of neurons. Strikingly, poor readers show an imprecise encoding of fast transients of speech in the auditory brainstem. Whether dyslexia risk genes are related to the quality of sound encoding in the auditory brainstem remains to be investigated. Here, we quantified the response consistency of speech-evoked brainstem responses to the acoustically presented syllable [da] in 159 genotyped, literate and preliterate children. When controlling for age, sex, familial risk and intelligence, partial correlation analyses associated a higher dyslexia risk loading with KIAA0319 with noisier responses. In contrast, a higher risk loading with DCDC2 was associated with a trend towards more stable responses. These results suggest that unstable representation of sound, and thus, reduced neural discrimination ability of stop consonants, occurred in genotypes carrying a higher amount of KIAA0319 risk alleles. Current data provide the first evidence that the dyslexia-associated gene KIAA0319 can alter brainstem responses and impair phoneme processing in the auditory brainstem. This brain-gene relationship provides insight into the complex relationships between phenotype and genotype thereby improving the understanding of the dyslexia-inherent complex multifactorial condition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.