Evidence map›Paper›PMID 28182761›Full record

ArticlePloS one2017

Kidney function and specific mortality in 60-80 years old post-myocardial infarction patients: A 10-year follow-up study.

Ellen K Hoogeveen, Johanna M Geleijnse, Erik J Giltay, Sabita S Soedamah-Muthu, Janette de Goede, Linda M Oude Griep, Theo Stijnen, Daan Kromhout

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Marine-derived n-3 fatty acids therapy for stroke.The Cochrane database of systematic reviews · 2022
    Pooled it
  3. Pooled it
  4. Marine-derived n-3 fatty acids therapy for stroke.The Cochrane database of systematic reviews · 2019
    Pooled it
  5. Article
  6. Article
  7. Article
  8. Article
  9. Diet and Kidney Function: a Literature Review.Current hypertension reports · 2020
    Review
  10. Dietary protein intake and kidney function decline after myocardial infarction: the Alpha Omega Cohort.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2020
    Article
  11. Article
  12. Article
  13. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ellen K HoogeveenDepartment of Nephrology, Jeroen Bosch Hospital, Den Bosch, the Netherlands.ORCID http://orcid.org/0000-0002-5482-2013
Johanna M GeleijnseDivision of Human Nutrition, Wageningen University, Wageningen, the Netherlands.
Erik J GiltayDepartment of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands.
Sabita S Soedamah-MuthuDivision of Human Nutrition, Wageningen University, Wageningen, the Netherlands.
Janette de GoedeDivision of Human Nutrition, Wageningen University, Wageningen, the Netherlands.
Linda M Oude GriepDivision of Human Nutrition, Wageningen University, Wageningen, the Netherlands.
Theo StijnenDepartment of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands.
Daan KromhoutDivision of Human Nutrition, Wageningen University, Wageningen, the Netherlands.
Wageningen University & Research · NLLeiden University Medical Center · NL

Funding

Alpha Omega TrialR01HL076200 · NHLBI · WAGENINGEN UNIVERSITY · PI KROMHOUT, DAAN · 2005 to 2008
$1.9M
NHLBI NIH HHS R01 HL076200
6 · The paper itself

Abstract

Chronic kidney disease (CKD) is highly prevalent among older post-myocardial infarction (MI) patients. It is not known whether CKD is an independent risk factor for mortality in older post-MI patients with optimal cardiovascular drug-treatment. Therefore, we studied the relation between kidney function and all-cause and specific mortality among older post-MI patients, without severe heart failure, who are treated with state-of-the-art pharmacotherapy. From 2002-2006, 4,561 Dutch post-MI patients were enrolled and followed until death or January 2012. We estimated Glomerular Filtration Rate (eGFR) with cystatin C (cysC) and creatinine (cr) using the CKD-EPI equations and analyzed the relation with any and major causes of death using Cox models and restricted cubic splines. Mean (SD) for age was 69 years (5.6), 79% were men, 17% smoked, 21% had diabetes, 90% used antihypertensive drugs, 98% used antithrombotic drugs and 85% used statins. Patients were divided into four categories of baseline eGFRcysC: ≥90 (33%; reference), 60-89 (47%), 30-59 (18%), and <30 (2%) ml/min/1.73m2. Median follow-up was 6.4 years. During follow-up, 873 (19%) patients died: 370 (42%) from cardiovascular causes, 309 (35%) from cancer, and 194 (22%) from other causes. After adjustment for age, sex and classic cardiovascular risk factor, hazard ratios (95%-confidence intervals) for any death according to the four eGFRcysC categories were: 1 (reference), 1.4 (1.1-1.7), 2.9 (2.3-3.6) and 4.4 (3.0-6.4). The hazard ratios of all-cause and cause-specific mortality increased linearly below kidney functions of 80 ml/min/1.73 m2. Weaker results were obtained for eGFRcr. To conclude, we found in optimal cardiovascular drug-treated post-MI patients an inverse graded relation between kidney function and mortality for both cardiovascular as well as non-cardiovascular causes. Risk of mortality increased linearly below kidney function of about 80 ml/min/1.73 m2.

Indexed as

Glomerular Filtration RateAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedMyocardial InfarctionRenal Insufficiency, ChronicSurvival Analysis

Identifiers

PMID28182761
PMCPMC5300181
OpenAlexW2587651486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.