Evidence map›Paper›PMID 28182690›Full record

Trial reportPloS one2017

Impact of dexmedetomidine on the incidence of delirium in elderly patients after cardiac surgery: A randomized controlled trial.

Xue Li, Jing Yang, Xiao-Lu Nie, Yan Zhang, Xue-Ying Li, Li-Huan Li, Dong-Xin Wang, Daqing Ma

5 registry-linked trialsOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 65 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 19 pooled it
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02267538 phase4completednot on this map

Impact of Dexmedetomidine on the Incidence of Postoperative Delirium in Patients After Cardiac Surgery: a Randomized, Double-blinded, and Placebo-controlled Clinical Trial

TypeinterventionalSponsorPeking University First HospitalRan2014 to 2015Enrolled285ConditionsDelirium, C.Surgical Procedure, Cardiac, Postoperative ComplicationsArmsdexmedetomidine hydrochloride for injection, 0.9% sodium chloride for injection
NCT02793986 nacompletednot on this map

Dexmedetomidine vs Propofol Sedation Reduces Postoperative Delirium in Patients Receiving Hip Arthroplasty.

TypeinterventionalSponsorThe First Affiliated Hospital of Anhui Medical UniversityRan2015 to 2017Enrolled296ConditionsAnesthesia, Local AnesthesiaArmspropofol, dexmedetomidine
NCT03624595 nacompletednot on this mapstarted 2019, after this paper: background citation

Effect of Low-dose Dexmedetomidine on Postoperative Delirium in Patients After Cardiac Surgery: A Multicenter, Double-blinded, Randomized Controlled Trial

TypeinterventionalSponsorDong-Xin WangRan2019 to 2025Enrolled504ConditionsCardiac Surgery, Cardiopulmonary Bypass, Dexmedetomidine, DeliriumArmsDexmedetomidine, Placebo
NCT04912518 narecruitingnot on this mapstarted 2021, after this paper: background citation

Cardioprotective Effect of Dexmedetomidine in Patients With ST-segment Elevation Myocardial Infarction: a Double-Blind, Multicenter, Randomized, Placebo-Controlled Clinical Trial

TypeinterventionalSponsorHarbin Medical UniversityRan2021 to 2025Enrolled250ConditionsST-segment Elevation Myocardial Infarction (STEMI), Percutaneous Coronary Intervention, CardioprotectionArmsDexmedetomidine (DEX), Placebo (Saline)
NCT07398066 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

DEXmedetomidine for Postoperative Analgesia and Delirium Prevention After NEUROsurgery: A Double-blinded Randomised Placebo-controlled Trial (DEX-NEURO Trial)

TypeinterventionalSponsorUniversity of MalayaRan2026 to 2027Enrolled60ConditionsNeurosurgery, Brain Cancer, MeningiomaArmsDexmedetomidine, Normal Saline (0.9% NaCl)
3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 19 syntheses or guidelines pooled it, 158 citations in OpenAlex.

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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Xue LiDepartment of Anesthesiology and Critical Care Medicine, Peking University First Hospital, Beijing, China.
Jing YangDepartment of Anesthesiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xiao-Lu NieCenter for Clinical Epidemiology & Evidence-Based Medicine, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Yan ZhangDepartment of Anesthesiology and Critical Care Medicine, Peking University First Hospital, Beijing, China.
Xue-Ying LiDepartment of Biostatistics, Peking University First Hospital, Beijing, China.
Li-Huan LiDepartment of Anesthesiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Dong-Xin WangDepartment of Anesthesiology and Critical Care Medicine, Peking University First Hospital, Beijing, China.ORCID http://orcid.org/0000-0002-3205-1836
Daqing MaSection of Anaesthetics, Pain Management and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom.
Peking University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNCapital Medical University · CNChelsea and Westminster Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDelirium is a frequent complication after cardiac surgery and its occurrence is associated with poor outcomes. The purpose of this study was to investigate the impact of perioperative dexmedetomidine administration on the incidence of delirium in elderly patients after cardiac surgery.

methodsThis randomized, double-blinded, and placebo-controlled trial was conducted in two tertiary hospitals in Beijing between December 1, 2014 and July 19, 2015. Eligible patients were randomized into two groups. Dexmedetomidine (DEX) was administered during anesthesia and early postoperative period for patients in the DEX group, whereas normal saline was administered in the same rate for the same duration for patients in the control (CTRL) group. The primary endpoint was the incidence of delirium during the first five days after surgery. Secondary endpoints included the cognitive function assessed on postoperative days 6 and 30, the overall incidence of non-delirium complications within 30 days after surgery, and the all-cause 30-day mortality.

resultsTwo hundred eighty-five patients were enrolled and randomized. Dexmedetomidine did not decrease the incidence of delirium (4.9% [7/142] in the DEX group vs 7.7% [11/143] in the CTRL group; OR 0.62, 95% CI 0.23 to 1.65, p = 0.341). Secondary endpoints were similar between the two groups; however, the incidence of pulmonary complications was slightly decreased (OR 0.51, 95% CI 0.26 to 1.00, p = 0.050) and the percentage of early extubation was significantly increased (OR 3.32, 95% CI 1.36 to 8.08, p = 0.008) in the DEX group. Dexmedetomidine decreased the required treatment for intraoperative tachycardia (21.1% [30/142] in the DEX group vs 33.6% [48/143] in the CTRL group, p = 0.019), but increased the required treatment for postoperative hypotension (84.5% [120/142] in the DEX group vs 69.9% [100/143] in the CTRL group, p = 0.003).

conclusionsDexmedetomidine administered during anesthesia and early postoperative period did not decrease the incidence of postoperative delirium in elderly patients undergoing elective cardiac surgery. However, considering the low delirium incidence, the trial might have been underpowered.

trial registrationClinicalTrials.gov NCT02267538.

Indexed as

Cardiac Surgical ProceduresEmergence DeliriumAgedAged, 80 and overAge FactorsDexmedetomidineDouble-Blind MethodFemaleHumansIncidenceMalePostoperative PeriodTime FactorsDexmedetomidine

Identifiers

PMID28182690
PMCPMC5300174
OpenAlexW2586157726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.